1i2z

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{{Seed}}
 
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[[Image:1i2z.png|left|200px]]
 
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==E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654==
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The line below this paragraph, containing "STRUCTURE_1i2z", creates the "Structure Box" on the page.
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<StructureSection load='1i2z' size='340' side='right'caption='[[1i2z]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1i2z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I2Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=654:4-(2-THIENYL)-1-(4-METHYLBENZYL)-1H-IMIDAZOLE'>654</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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{{STRUCTURE_1i2z| PDB=1i2z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2z OCA], [https://pdbe.org/1i2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i2z RCSB], [https://www.ebi.ac.uk/pdbsum/1i2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/1i2z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i2z ConSurf].
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<div style="clear:both"></div>
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===E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654===
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==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11514139}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11514139 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11514139}}
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==About this Structure==
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1I2Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2Z OCA].
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==Reference==
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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11514139 11514139]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Heerding, D A.]]
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[[Category: Heerding DA]]
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[[Category: Janson, C A.]]
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[[Category: Janson CA]]
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[[Category: Miller, W H.]]
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[[Category: Miller WH]]
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[[Category: Payne, D J.]]
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[[Category: Payne DJ]]
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[[Category: Qiu, X.]]
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[[Category: Qiu X]]
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[[Category: Antibiotic]]
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[[Category: Enoyl reductase]]
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[[Category: Nad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:20:06 2008''
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Current revision

E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654

PDB ID 1i2z

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