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1i3e

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{{Seed}}
 
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[[Image:1i3e.png|left|200px]]
 
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<!--
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==HUMAN AZIDO-MET HEMOGLOBIN BART'S (GAMMA4)==
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The line below this paragraph, containing "STRUCTURE_1i3e", creates the "Structure Box" on the page.
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<StructureSection load='1i3e' size='340' side='right'caption='[[1i3e]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1i3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I3E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_1i3e| PDB=1i3e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i3e OCA], [https://pdbe.org/1i3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i3e RCSB], [https://www.ebi.ac.uk/pdbsum/1i3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i3e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HBG1_HUMAN HBG1_HUMAN] Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/1i3e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i3e ConSurf].
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<div style="clear:both"></div>
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===HUMAN AZIDO-MET HEMOGLOBIN BART'S (GAMMA4)===
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==See Also==
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11514664}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11514664 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11514664}}
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==Disease==
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Known disease associated with this structure: Fetal hemoglobin quantitative trait locus 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142200 142200]]
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==About this Structure==
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1I3E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I3E OCA].
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==Reference==
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Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia., Kidd RD, Baker HM, Mathews AJ, Brittain T, Baker EN, Protein Sci. 2001 Sep;10(9):1739-49. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11514664 11514664]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baker, E N.]]
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[[Category: Baker EN]]
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[[Category: Baker, H M.]]
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[[Category: Baker HM]]
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[[Category: Brittain, T.]]
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[[Category: Brittain T]]
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[[Category: Kidd, R D.]]
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[[Category: Kidd RD]]
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[[Category: Mathews, A J.]]
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[[Category: Mathews AJ]]
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[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:21:09 2008''
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Current revision

HUMAN AZIDO-MET HEMOGLOBIN BART'S (GAMMA4)

PDB ID 1i3e

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