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1i69

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{{Seed}}
 
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[[Image:1i69.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE REDUCED FORM OF OXYR==
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The line below this paragraph, containing "STRUCTURE_1i69", creates the "Structure Box" on the page.
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<StructureSection load='1i69' size='340' side='right'caption='[[1i69]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1i69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I69 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
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{{STRUCTURE_1i69| PDB=1i69 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i69 OCA], [https://pdbe.org/1i69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i69 RCSB], [https://www.ebi.ac.uk/pdbsum/1i69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i69 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OXYR_ECOLI OXYR_ECOLI] Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/1i69_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i69 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THE REDUCED FORM OF OXYR===
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11301006}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11301006 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11301006}}
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==About this Structure==
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1I69 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I69 OCA].
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==Reference==
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Structural basis of the redox switch in the OxyR transcription factor., Choi H, Kim S, Mukhopadhyay P, Cho S, Woo J, Storz G, Ryu S, Cell. 2001 Apr 6;105(1):103-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11301006 11301006]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Choi, H.]]
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[[Category: Choi H]]
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[[Category: Kim, S.]]
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[[Category: Kim S]]
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[[Category: Ryu, S.]]
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[[Category: Ryu S]]
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[[Category: Oxyr regulatory domain]]
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[[Category: Reduced form]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:28:25 2008''
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Current revision

CRYSTAL STRUCTURE OF THE REDUCED FORM OF OXYR

PDB ID 1i69

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