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1ia0

From Proteopedia

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{{Seed}}
 
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[[Image:1ia0.png|left|200px]]
 
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==KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM==
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The line below this paragraph, containing "STRUCTURE_1ia0", creates the "Structure Box" on the page.
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<SX load='1ia0' size='340' side='right' viewer='molstar' caption='[[1ia0]], [[Resolution|resolution]] 15.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ia0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IA0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TXL:TAXOTERE'>TXL</scene></td></tr>
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{{STRUCTURE_1ia0| PDB=1ia0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ia0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ia0 OCA], [https://pdbe.org/1ia0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ia0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ia0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ia0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TBA1A_PIG TBA1A_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/1ia0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ia0 ConSurf].
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<div style="clear:both"></div>
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===KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM===
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==See Also==
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_11373668}}, adds the Publication Abstract to the page
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</SX>
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(as it appears on PubMed at http://www.pubmed.gov), where 11373668 is the PubMed ID number.
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_11373668}}
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==About this Structure==
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1IA0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IA0 OCA].
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==Reference==
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Switch-based mechanism of kinesin motors., Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N, Nature. 2001 May 24;411(6836):439-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373668 11373668]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
 
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Fletterick, R J.]]
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[[Category: Fletterick RJ]]
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[[Category: Hirokawa, N.]]
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[[Category: Hirokawa N]]
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[[Category: Kikkawa, M.]]
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[[Category: Kikkawa M]]
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[[Category: Okada, Y.]]
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[[Category: Okada Y]]
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[[Category: Sablin, E P.]]
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[[Category: Sablin EP]]
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[[Category: Yajima, H.]]
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[[Category: Yajima H]]
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[[Category: Cryo-electron microscopy]]
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[[Category: Fitting of x-ray structures into cryo-em reconstruction]]
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[[Category: Kif1a]]
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[[Category: Microtubule]]
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[[Category: Tubulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:38:54 2008''
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Current revision

KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM

1ia0, resolution 15.00Å

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