1ici

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{{Seed}}
 
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[[Image:1ici.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1ici", creates the "Structure Box" on the page.
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<StructureSection load='1ici' size='340' side='right'caption='[[1ici]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ici]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ICI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1ici| PDB=1ici | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ici FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ici OCA], [https://pdbe.org/1ici PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ici RCSB], [https://www.ebi.ac.uk/pdbsum/1ici PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ici ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX===
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== Function ==
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[https://www.uniprot.org/uniprot/NPD1_ARCFU NPD1_ARCFU] NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription (By similarity).<ref>PMID:10841563</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11336676 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/1ici_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11336676}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1ICI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICI OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ici ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of a SIR2 homolog-NAD complex., Min J, Landry J, Sternglanz R, Xu RM, Cell. 2001 Apr 20;105(2):269-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11336676 11336676]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Landry, J.]]
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[[Category: Landry J]]
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[[Category: Min, J.]]
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[[Category: Min J]]
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[[Category: Sternglanz, R.]]
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[[Category: Sternglanz R]]
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[[Category: Xu, R M.]]
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[[Category: Xu R-M]]
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[[Category: Nad-binding]]
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[[Category: Protein deacetylase]]
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[[Category: Rossmann fold]]
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[[Category: Zinc ribbon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:45:36 2008''
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Current revision

CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX

PDB ID 1ici

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