1ien

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:41, 29 November 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1ien.png|left|200px]]
 
-
<!--
+
==SOLUTION STRUCTURE OF TIA==
-
The line below this paragraph, containing "STRUCTURE_1ien", creates the "Structure Box" on the page.
+
<StructureSection load='1ien' size='340' side='right'caption='[[1ien]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ien]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_tulipa Conus tulipa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IEN FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-
{{STRUCTURE_1ien| PDB=1ien | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ien FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ien OCA], [https://pdbe.org/1ien PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ien RCSB], [https://www.ebi.ac.uk/pdbsum/1ien PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ien ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CA1A_CONTU CA1A_CONTU] Allosteric inhibitor of alpha-1B adrenergic receptors (ADRA1B). Binds to an allosteric modulatory site on transmembrane helix 6 and 7 at the base of extracellular loop 3 of ADRA1B (PubMed:23184947). Also weekly inhibits alpha-1A (ADRA1A) and alpha-1D (ADRA1D) adrenergic receptors in a competive manner (PubMed:15194691). Potently inhibits contractions of vas deferens, spleen and aorta in response to noradrenaline (PubMed:15680270).<ref>PMID:11528421</ref> <ref>PMID:12824165</ref> <ref>PMID:15194691</ref> <ref>PMID:15680270</ref> <ref>PMID:23184947</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha1-adrenoceptors (rho-TIA from the fish-hunting Conus tulipa), and the second class targets the neuronal noradrenaline transporter (chi-MrIA and chi-MrIB from the mollusk-hunting C. marmoreus). rho-TIA and chi-MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.
-
===SOLUTION STRUCTURE OF TIA===
+
Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.,Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ Nat Neurosci. 2001 Sep;4(9):902-7. PMID:11528421<ref>PMID:11528421</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_11528421}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1ien" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 11528421 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_11528421}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Conus tulipa]]
-
1IEN is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEN OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Adams DA]]
-
==Reference==
+
[[Category: Adams DJ]]
-
Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter., Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ, Nat Neurosci. 2001 Sep;4(9):902-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11528421 11528421]
+
[[Category: Alewood PF]]
-
[[Category: Single protein]]
+
[[Category: Atkins A]]
-
[[Category: Adams, D A.]]
+
[[Category: Craik DJ]]
-
[[Category: Adams, D J.]]
+
[[Category: Gehrmann J]]
-
[[Category: Alewood, P F.]]
+
[[Category: Lewis RJ]]
-
[[Category: Atkins, A.]]
+
[[Category: Loughnan ML]]
-
[[Category: Craik, D J.]]
+
[[Category: Palant E]]
-
[[Category: Gehrmann, J.]]
+
[[Category: Sharpe IA]]
-
[[Category: Lewis, R J.]]
+
[[Category: Thomas L]]
-
[[Category: Loughnan, M L.]]
+
-
[[Category: Palant, E.]]
+
-
[[Category: Sharpe, I A.]]
+
-
[[Category: Thomas, L.]]
+
-
[[Category: Alpha1-adrenoceptor]]
+
-
[[Category: Conotoxin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:51:18 2008''
+

Current revision

SOLUTION STRUCTURE OF TIA

PDB ID 1ien

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ien"
Personal tools