1ij2

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{{Seed}}
 
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[[Image:1ij2.png|left|200px]]
 
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==GCN4-pVTL Coiled-coil Trimer with Threonine at the a(16) position==
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The line below this paragraph, containing "STRUCTURE_1ij2", creates the "Structure Box" on the page.
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<StructureSection load='1ij2' size='340' side='right'caption='[[1ij2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ij2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJ2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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{{STRUCTURE_1ij2| PDB=1ij2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ij2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij2 OCA], [https://pdbe.org/1ij2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ij2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ij2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Coiled coils, estimated to constitute 3-5% of the encoded residues in most genomes, are characterized by a heptad repeat, (abcdefg)(n), where the buried a and d positions form the interface between multiple alpha-helices. Although generally hydrophobic, a substantial fraction ( approximately 20%) of these a- and d-position residues are polar or charged. We constructed variants of the well-characterized coiled coil GCN4-p1 with a single polar residue (Asn, Gln, Ser, or Thr) at either an a or a d position. The stability and oligomeric specificity of each variant were measured, and crystal structures of coiled-coil trimers with threonine or serine at either an a or a d position were determined. The structures show how single polar residues in the interface affect not only local packing, but also overall coiled-coil geometry as seen by changes in the Crick supercoil parameters and core cavity volumes.
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===GCN4-pVTL Coiled-coil Trimer with Threonine at the a(16) position===
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Buried polar residues in coiled-coil interfaces.,Akey DL, Malashkevich VN, Kim PS Biochemistry. 2001 May 29;40(21):6352-60. PMID:11371197<ref>PMID:11371197</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ij2" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11371197}}, adds the Publication Abstract to the page
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*[[Gcn4 3D Structures|Gcn4 3D Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11371197 is the PubMed ID number.
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*[[Gnc4 3D Structures|Gnc4 3D Structures]]
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== References ==
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{{ABSTRACT_PUBMED_11371197}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1IJ2 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ2 OCA].
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae S288C]]
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==Reference==
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[[Category: Akey DL]]
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Buried polar residues in coiled-coil interfaces., Akey DL, Malashkevich VN, Kim PS, Biochemistry. 2001 May 29;40(21):6352-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11371197 11371197]
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[[Category: Kim PS]]
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[[Category: Single protein]]
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[[Category: Malashkevich VN]]
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[[Category: Akey, D L.]]
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[[Category: Kim, P S.]]
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[[Category: Malashkevich, V N.]]
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[[Category: Gcn4 coiled coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:18:17 2008''
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Current revision

GCN4-pVTL Coiled-coil Trimer with Threonine at the a(16) position

PDB ID 1ij2

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