1il5

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{{Seed}}
 
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[[Image:1il5.png|left|200px]]
 
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==STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE (DDP)==
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The line below this paragraph, containing "STRUCTURE_1il5", creates the "Structure Box" on the page.
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<StructureSection load='1il5' size='340' side='right'caption='[[1il5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1il5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IL5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DDP:2,4-DIAMINO-4,6-DIHYDROXYPYRIMIDINE'>DDP</scene></td></tr>
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{{STRUCTURE_1il5| PDB=1il5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1il5 OCA], [https://pdbe.org/1il5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1il5 RCSB], [https://www.ebi.ac.uk/pdbsum/1il5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1il5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/1il5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1il5 ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE (DDP)===
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==See Also==
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*[[Ricin 3D structures|Ricin 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11754581 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11754581}}
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==About this Structure==
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1IL5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IL5 OCA].
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==Reference==
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Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition., Miller DJ, Ravikumar K, Shen H, Suh JK, Kerwin SM, Robertus JD, J Med Chem. 2002 Jan 3;45(1):90-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11754581 11754581]
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[[Category: Ricinus communis]]
[[Category: Ricinus communis]]
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[[Category: Single protein]]
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[[Category: Kerwin SM]]
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[[Category: RRNA N-glycosylase]]
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[[Category: Miller DJ]]
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[[Category: Kerwin, S M.]]
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[[Category: Ravikumar K]]
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[[Category: Miller, D J.]]
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[[Category: Robertus JD]]
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[[Category: Ravikumar, K.]]
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[[Category: Shen H]]
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[[Category: Robertus, J D.]]
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[[Category: Suh J-K]]
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[[Category: Shen, H.]]
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[[Category: Suh, J K.]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Ribosome-inhibiting protein]]
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[[Category: Structure-based design]]
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[[Category: Toxin-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:26:29 2008''
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Current revision

STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE (DDP)

PDB ID 1il5

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