1imi

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[[Image:1imi.png|left|200px]]
 
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==SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1==
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The line below this paragraph, containing "STRUCTURE_1imi", creates the "Structure Box" on the page.
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<StructureSection load='1imi' size='340' side='right'caption='[[1imi]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1imi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IMI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_1imi| PDB=1imi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1imi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imi OCA], [https://pdbe.org/1imi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1imi RCSB], [https://www.ebi.ac.uk/pdbsum/1imi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1imi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A 600 MHz NMR study of alpha-conotoxin ImI from Conus imperialis, targeting the alpha7 neuronal nicotinic acetylcholine receptor (nAChR), is presented. ImI backbone spatial structure is well defined basing on the NOEs, spin-spin coupling constants, and amide protons hydrogen-deuterium exchange data: rmsd of the backbone atom coordinates at the 2-12 region is 0.28 A in the 20 best structures. The structure is described as a type I beta-turn (positions 2-5) followed by a distorted helix (positions 5-11). Similar structural patterns can be found in all neuronal-specific alpha-conotoxins. Highly mobile side chains of the Asp-5, Arg-7 and Trp-10 residues form a single site for ImI binding to the alpha7 receptor. When depicted with opposite directions of the polypeptide chains, the ImI helix and the tip of the central loop of long chain snake neurotoxins demonstrate a common scaffold and similar positioning of the functional side chains, both of these structural elements appearing essential for binding to the neuronal nAChRs.
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===SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1===
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NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors.,Maslennikov IV, Shenkarev ZO, Zhmak MN, Ivanov VT, Methfessel C, Tsetlin VI, Arseniev AS FEBS Lett. 1999 Feb 12;444(2-3):275-80. PMID:10050774<ref>PMID:10050774</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1imi" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10050774 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10050774}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1IMI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMI OCA].
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==Reference==
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NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors., Maslennikov IV, Shenkarev ZO, Zhmak MN, Ivanov VT, Methfessel C, Tsetlin VI, Arseniev AS, FEBS Lett. 1999 Feb 12;444(2-3):275-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10050774 10050774]
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[[Category: Conus imperialis]]
[[Category: Conus imperialis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arseniev, A S.]]
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[[Category: Arseniev AS]]
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[[Category: Ivanov, V T.]]
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[[Category: Ivanov VT]]
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[[Category: Maslennikov, I V.]]
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[[Category: Maslennikov IV]]
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[[Category: Shenkarev, Z O.]]
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[[Category: Shenkarev ZO]]
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[[Category: Tsetlin, V I.]]
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[[Category: Tsetlin VI]]
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[[Category: Zhmak, M N.]]
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[[Category: Zhmak MN]]
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[[Category: Acetylcholine receptor inhibitor]]
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[[Category: Antagonist]]
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[[Category: Neurotoxin]]
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[[Category: Nicotinic acetylcholine receptor]]
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[[Category: Postsynaptic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:32:41 2008''
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Current revision

SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1

PDB ID 1imi

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