1iq3

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{{Seed}}
 
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[[Image:1iq3.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE EPS15 HOMOLOGY DOMAIN OF A HUMAN POB1==
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The line below this paragraph, containing "STRUCTURE_1iq3", creates the "Structure Box" on the page.
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<StructureSection load='1iq3' size='340' side='right'caption='[[1iq3]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1iq3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IQ3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1iq3| PDB=1iq3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iq3 OCA], [https://pdbe.org/1iq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1iq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iq3 ProSAT], [https://www.topsan.org/Proteins/RSGI/1iq3 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/REPS2_HUMAN REPS2_HUMAN] Involved in growth factor signaling through its influence on the Ral signaling pathway.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/1iq3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iq3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of the Eps15 homology (EH) domain of a human POB1 (partner of RaIBP1) has been determined by uniform 13C/15N labeling and heteronuclear multidimensional nuclear magnetic resonance spectroscopy. The POB1 EH domain consists of two EF-hand structures, and the second one binds a calcium ion. In the calcium-bound state, the orientation of the fourth alpha-helix relative to the other helices of the POB1 EH domain is slightly different from that of calbindin, and much more different from those of calmodulin and troponin C, on the basis of their atomic coordinates.
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===SOLUTION STRUCTURE OF THE EPS15 HOMOLOGY DOMAIN OF A HUMAN POB1===
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Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1).,Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S FEBS Lett. 1999 Jan 15;442(2-3):138-42. PMID:9928989<ref>PMID:9928989</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9928989}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1iq3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9928989 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9928989}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1IQ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IQ3 OCA].
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==Reference==
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Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)., Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S, FEBS Lett. 1999 Jan 15;442(2-3):138-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9928989 9928989]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Iwahara, J.]]
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[[Category: Iwahara J]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Kikuchi, A.]]
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[[Category: Kikuchi A]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Ef-hand domain]]
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[[Category: Pob1 eh domain]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:47:19 2008''
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Current revision

SOLUTION STRUCTURE OF THE EPS15 HOMOLOGY DOMAIN OF A HUMAN POB1

PDB ID 1iq3

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