1iqo

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{{Seed}}
 
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[[Image:1iqo.png|left|200px]]
 
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==Solution structure of MTH1880 from methanobacterium thermoautotrophicum==
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The line below this paragraph, containing "STRUCTURE_1iqo", creates the "Structure Box" on the page.
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<StructureSection load='1iqo' size='340' side='right'caption='[[1iqo]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1iqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter Methanothermobacter]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IQO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iqo OCA], [https://pdbe.org/1iqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iqo RCSB], [https://www.ebi.ac.uk/pdbsum/1iqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iqo ProSAT]</span></td></tr>
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{{STRUCTURE_1iqo| PDB=1iqo | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O27908_METTH O27908_METTH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/1iqo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iqo ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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MTH1880 is a hypothetical protein from Methanobacterium thermoautotrophicum, a target organism of structural genomics. The solution structure determined by NMR spectroscopy demonstrates a typical alpha + beta-fold found in many proteins with different functions. The molecular surface of the protein reveals a small, highly acidic pocket comprising loop B (Asp36, Asp37, Asp38), the end of beta2 (Glu39), and loop D (Ser57, Ser58, Ser61), indicating that the protein would have a possible cation binding site. The NMR resonances of several amino acids within the acidic binding pocket in MTH1880, shifted upon addition of calcium ion. This calcium binding motif and overall topology of MTH1880 differ from those of other calcium binding proteins. MTH1880 did not show a calcium-induced conformational change typical of calcium sensor proteins. Therefore, we propose that the MTH1880 protein contains a novel motif for calcium-specific binding, and may function as a calcium buffering protein.
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===Solution structure of MTH1880 from methanobacterium thermoautotrophicum===
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Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum.,Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W Protein Sci. 2004 Apr;13(4):1148-54. PMID:15044740<ref>PMID:15044740</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15044740}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1iqo" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15044740 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15044740}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1IQO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter Methanothermobacter]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IQO OCA].
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==Reference==
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Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum., Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W, Protein Sci. 2004 Apr;13(4):1148-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15044740 15044740]
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[[Category: Methanothermobacter]]
[[Category: Methanothermobacter]]
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[[Category: Single protein]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bang E]]
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[[Category: Bang, E.]]
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[[Category: Jung JW]]
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[[Category: Jung, J W.]]
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[[Category: Lee CH]]
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[[Category: Lee, C H.]]
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[[Category: Lee W]]
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[[Category: Lee, W.]]
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[[Category: Shin J]]
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[[Category: Shin, J.]]
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[[Category: Yee A]]
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[[Category: Yee, A.]]
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[[Category: Anti-parallel]]
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[[Category: Beta-alpha]]
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[[Category: Calcium binding]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:49:26 2008''
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Current revision

Solution structure of MTH1880 from methanobacterium thermoautotrophicum

PDB ID 1iqo

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OCA

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