1j57

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{{Seed}}
 
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[[Image:1j57.png|left|200px]]
 
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==NuiA==
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The line below this paragraph, containing "STRUCTURE_1j57", creates the "Structure Box" on the page.
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<StructureSection load='1j57' size='340' side='right'caption='[[1j57]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1j57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_sp._PCC_7120_=_FACHB-418 Nostoc sp. PCC 7120 = FACHB-418]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J57 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j57 OCA], [https://pdbe.org/1j57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j57 RCSB], [https://www.ebi.ac.uk/pdbsum/1j57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j57 ProSAT]</span></td></tr>
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{{STRUCTURE_1j57| PDB=1j57 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q7A260_NOSS1 Q7A260_NOSS1]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nuclease A (NucA) from Anabaena sp. is a non-specific endonuclease able to degrade single and double-stranded DNA and RNA. The endonucleolytic activity is inhibited by the nuclease A inhibitor (NuiA), which binds to NucA with 1:1 stoichiometry and picomolar affinity. In order to better understand the mechanism of inhibition, the solution structure of NuiA was determined by NMR methods. The fold of NuiA is an alpha-beta-alpha sandwich but standard database searches by DALI and TOP revealed no structural homologies. A visual inspection of alpha-beta-alpha folds in the CATH database revealed similarities to the PR-1-like fold (SCOP nomenclature). The similarities include the ordering of secondary structural elements, a single helix on one face of the alpha-beta-alpha sandwich, and three helices on the other face. However, a major difference is in the IV helix, which in the PR-1 fold is short and perpendicular to the I and III helices, but in NuiA is long and parallel to the I and III helices. Additionally, a strand insertion in the beta-sheet makes the NuiA beta-sheet completely antiparallel in organization. The fast time-scale motions of NuiA, characterized by enhanced flexibility of the extended loop between helices III and IV, also show similarities to P14a, which is a PR-1 fold. We propose that the purpose of the PR-1 fold is to form a stable scaffold to present this extended structure for biological interactions with other proteins. This hypothesis is supported by data that show that when NuiA is bound to NucA significant changes in chemical shift occur in the extended loop between helices III and IV.
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===NuiA===
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The nuclease A inhibitor represents a new variation of the rare PR-1 fold.,Kirby TW, Mueller GA, DeRose EF, Lebetkin MS, Meiss G, Pingoud A, London RE J Mol Biol. 2002 Jul 19;320(4):771-82. PMID:12095254<ref>PMID:12095254</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12095254}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1j57" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12095254 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12095254}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1J57 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anabaena_sp. Anabaena sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J57 OCA].
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[[Category: Nostoc sp. PCC 7120 = FACHB-418]]
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[[Category: DeRose EF]]
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==Reference==
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[[Category: Kirby TW]]
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The nuclease A inhibitor represents a new variation of the rare PR-1 fold., Kirby TW, Mueller GA, DeRose EF, Lebetkin MS, Meiss G, Pingoud A, London RE, J Mol Biol. 2002 Jul 19;320(4):771-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12095254 12095254]
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[[Category: Lebetkin MS]]
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[[Category: Anabaena sp.]]
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[[Category: London RE]]
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[[Category: Single protein]]
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[[Category: Meiss G]]
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[[Category: DeRose, E F.]]
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[[Category: Mueller GA]]
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[[Category: Kirby, T W.]]
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[[Category: Pingoud A]]
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[[Category: Lebetkin, M S.]]
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[[Category: London, R E.]]
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[[Category: Meiss, G.]]
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[[Category: Mueller, G A.]]
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[[Category: Pingoud, A.]]
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[[Category: Nuca]]
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[[Category: Nuclease some]]
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[[Category: Nuclease a inhibitor]]
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[[Category: Nuclease inhibitor]]
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[[Category: Nuia]]
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[[Category: Pr-1-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:31:07 2008''
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Current revision

NuiA

PDB ID 1j57

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