1jao

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{{Seed}}
 
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[[Image:1jao.png|left|200px]]
 
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==COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)==
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The line below this paragraph, containing "STRUCTURE_1jao", creates the "Structure Box" on the page.
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<StructureSection load='1jao' size='340' side='right'caption='[[1jao]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jao]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JAO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0D3:N-[(2S)-2-BENZYL-3-SULFANYLPROPANOYL]-L-ALANYLGLYCINAMIDE'>0D3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1jao| PDB=1jao | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jao OCA], [https://pdbe.org/1jao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jao RCSB], [https://www.ebi.ac.uk/pdbsum/1jao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jao ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/1jao_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jao ConSurf].
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<div style="clear:both"></div>
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===COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)===
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_7737183}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7737183 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7737183}}
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==About this Structure==
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1JAO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAO OCA].
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==Reference==
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X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design., Grams F, Reinemer P, Powers JC, Kleine T, Pieper M, Tschesche H, Huber R, Bode W, Eur J Biochem. 1995 Mar 15;228(3):830-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7737183 7737183]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Neutrophil collagenase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Bode W]]
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[[Category: Bode, W.]]
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[[Category: Grams F]]
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[[Category: Grams, F.]]
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[[Category: Huber R]]
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[[Category: Huber, R.]]
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[[Category: Kleine T]]
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[[Category: Kleine, T.]]
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[[Category: Piper M]]
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[[Category: Piper, M.]]
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[[Category: Powers JC]]
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[[Category: Powers, J C.]]
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[[Category: Reinemer P]]
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[[Category: Reinemer, P.]]
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[[Category: Tschesche H]]
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[[Category: Tschesche, H.]]
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[[Category: Metalloprotease]]
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[[Category: Metzincin]]
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[[Category: Zinc-endopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 17:38:54 2008''
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Current revision

COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)

PDB ID 1jao

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