1jbd

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{{Seed}}
 
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[[Image:1jbd.png|left|200px]]
 
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==NMR Structure of the Complex Between alpha-bungarotoxin and a Mimotope of the Nicotinic Acetylcholine Receptor==
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The line below this paragraph, containing "STRUCTURE_1jbd", creates the "Structure Box" on the page.
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<StructureSection load='1jbd' size='340' side='right'caption='[[1jbd]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jbd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hn7 1hn7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JBD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbd OCA], [https://pdbe.org/1jbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jbd RCSB], [https://www.ebi.ac.uk/pdbsum/1jbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbd ProSAT]</span></td></tr>
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{{STRUCTURE_1jbd| PDB=1jbd | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3L21A_BUNMU 3L21A_BUNMU] Binds with high affinity to muscular (tested on Torpedo marmorata, Kd=0.4 nM) and neuronal (tested on chimeric alpha-7/CHRNA7, Kd=0.95 nM) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (PubMed:9305882). It also shows an activity on GABA(A) receptors (PubMed:16549768, PubMed:25634239). It antagonises GABA-activated currents with high potency when tested on primary hippocampal neurons (PubMed:25634239). It inhibits recombinantly expressed GABA(A) receptors composed of alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits with high potency (62.3% inhibition at 20 uM of toxin) (PubMed:25634239). It also shows a weaker inhibition on GABA(A) receptors composed of alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits, alpha-4-beta-2-gamma-2 (GABRA4-GABRB2-GABRG2) subunits, and alpha-5-beta-2-gamma-2 (GABRA5-GABRB2-GABRG2) subunits (PubMed:25634239). A very weak inhibition is also observed on GABA(A) receptor composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) (PubMed:26221036). It has also been shown to bind and inhibit recombinant GABA(A) receptor beta-3/GABRB3 subunit (Kd=about 50 nM) (PubMed:16549768). In addition, it blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 uM) (PubMed:9840221).<ref>PMID:16549768</ref> <ref>PMID:25634239</ref> <ref>PMID:9305882</ref> <ref>PMID:9840221</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/1jbd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jbd ConSurf].
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<div style="clear:both"></div>
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===NMR Structure of the Complex Between alpha-bungarotoxin and a Mimotope of the Nicotinic Acetilcholine Receptor===
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==See Also==
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*[[Bungarotoxin 3D structures|Bungarotoxin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11814338}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11814338 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11814338}}
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==About this Structure==
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1JBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hn7 1hn7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBD OCA].
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==Reference==
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NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor., Scarselli M, Spiga O, Ciutti A, Bernini A, Bracci L, Lelli B, Lozzi L, Calamandrei D, Di Maro D, Klein S, Niccolai N, Biochemistry. 2002 Feb 5;41(5):1457-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11814338 11814338]
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[[Category: Bungarus multicinctus]]
[[Category: Bungarus multicinctus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bernini, A.]]
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[[Category: Bernini A]]
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[[Category: Bracci, L.]]
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[[Category: Bracci L]]
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[[Category: Calamandrei, D.]]
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[[Category: Calamandrei D]]
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[[Category: Ciutti, A.]]
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[[Category: Ciutti A]]
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[[Category: Klein, S.]]
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[[Category: Di Maro D]]
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[[Category: Lelli, B.]]
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[[Category: Klein S]]
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[[Category: Lozzi, L.]]
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[[Category: Lelli B]]
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[[Category: Maro, D Di.]]
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[[Category: Lozzi L]]
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[[Category: Niccolai, N.]]
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[[Category: Niccolai N]]
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[[Category: Scarselli, M.]]
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[[Category: Scarselli M]]
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[[Category: Spiga, O.]]
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[[Category: Spiga O]]
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[[Category: Achr]]
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[[Category: Alpha-bungarotoxin]]
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[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 19:57:54 2008''
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Current revision

NMR Structure of the Complex Between alpha-bungarotoxin and a Mimotope of the Nicotinic Acetylcholine Receptor

PDB ID 1jbd

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