1jbj

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{{Seed}}
 
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[[Image:1jbj.png|left|200px]]
 
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==CD3 Epsilon and gamma Ectodomain Fragment Complex in Single-Chain Construct==
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The line below this paragraph, containing "STRUCTURE_1jbj", creates the "Structure Box" on the page.
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<StructureSection load='1jbj' size='340' side='right'caption='[[1jbj]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jbj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JBJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbj OCA], [https://pdbe.org/1jbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jbj RCSB], [https://www.ebi.ac.uk/pdbsum/1jbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbj ProSAT]</span></td></tr>
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{{STRUCTURE_1jbj| PDB=1jbj | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD3E_MOUSE CD3E_MOUSE] The CD3 complex mediates signal transduction.[https://www.uniprot.org/uniprot/CD3G_MOUSE CD3G_MOUSE] Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G (PubMed:25920998).[UniProtKB:P09693]<ref>PMID:25920998</ref> <ref>PMID:9524111</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/1jbj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jbj ConSurf].
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<div style="clear:both"></div>
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===CD3 Epsilon and gamma Ectodomain Fragment Complex in Single-Chain Construct===
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==See Also==
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*[[CD3 3D structures|CD3 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11439187}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11439187 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_11439187}}
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==About this Structure==
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1JBJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBJ OCA].
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==Reference==
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Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer., Sun ZJ, Kim KS, Wagner G, Reinherz EL, Cell. 2001 Jun 29;105(7):913-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11439187 11439187]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Kim KS]]
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[[Category: Kim, K S.]]
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[[Category: Reinherz EL]]
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[[Category: Reinherz, E L.]]
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[[Category: Sun Z-YJ]]
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[[Category: Sun, Z Y.J.]]
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[[Category: Wagner G]]
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[[Category: Wagner, G.]]
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[[Category: Beta-sheet]]
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[[Category: C2-set immunoglobulin superfamily]]
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[[Category: H-bonded g strand pair]]
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[[Category: Single-chain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 19:58:31 2008''
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Current revision

CD3 Epsilon and gamma Ectodomain Fragment Complex in Single-Chain Construct

PDB ID 1jbj

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