1jeh

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{{Seed}}
 
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[[Image:1jeh.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF YEAST E3, LIPOAMIDE DEHYDROGENASE==
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The line below this paragraph, containing "STRUCTURE_1jeh", creates the "Structure Box" on the page.
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<StructureSection load='1jeh' size='340' side='right'caption='[[1jeh]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jeh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JEH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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{{STRUCTURE_1jeh| PDB=1jeh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jeh OCA], [https://pdbe.org/1jeh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jeh RCSB], [https://www.ebi.ac.uk/pdbsum/1jeh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jeh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DLDH_YEAST DLDH_YEAST] Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/1jeh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jeh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of eucaryotic lipoamide dehydrogenase from yeast has been determined by an X-ray analysis at 2.7 (partially at 2.4) A resolution. The enzyme has two identical subunits related by a pseudo twofold symmetry. The tertiary structure is similar to those of other procaryotic enzymes. The active site, consisting of FAD, Cys44, and Cys49 from one subunit and His457' from the other subunit, is highly conserved. This enzyme is directly bound to the core protein E2 of the 2-oxoglutarate dehydrogenase complex, whereas it is bound to the pyruvate dehydrogenase complex through a protein X. The calculated electrostatic potential suggests two characteristic regions for binding with these two proteins.
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===CRYSTAL STRUCTURE OF YEAST E3, LIPOAMIDE DEHYDROGENASE===
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Crystal structure of eucaryotic E3, lipoamide dehydrogenase from yeast.,Toyoda T, Suzuki K, Sekiguchi T, Reed LJ, Takenaka A J Biochem. 1998 Apr;123(4):668-74. PMID:9538259<ref>PMID:9538259</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1jeh" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9538259}}, adds the Publication Abstract to the page
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*[[Dihydrolipoamide dehydrogenase|Dihydrolipoamide dehydrogenase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9538259 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9538259}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1JEH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JEH OCA].
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==Reference==
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Crystal structure of eucaryotic E3, lipoamide dehydrogenase from yeast., Toyoda T, Suzuki K, Sekiguchi T, Reed LJ, Takenaka A, J Biochem. 1998 Apr;123(4):668-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9538259 9538259]
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[[Category: Dihydrolipoyl dehydrogenase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Reed J]]
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[[Category: Reed, J.]]
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[[Category: Sekigushi T]]
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[[Category: Sekigushi, T.]]
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[[Category: Suzuki K]]
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[[Category: Suzuki, K.]]
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[[Category: Takenaka A]]
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[[Category: Takenaka, A.]]
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[[Category: Toyoda T]]
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[[Category: Toyoda, T.]]
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[[Category: 2-oxoglutarate dehydrogenase complex]]
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[[Category: Pyruvate dehydrogenase complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:07:13 2008''
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Current revision

CRYSTAL STRUCTURE OF YEAST E3, LIPOAMIDE DEHYDROGENASE

PDB ID 1jeh

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