1jfv

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{{Seed}}
 
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[[Image:1jfv.png|left|200px]]
 
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==X-Ray Structure of oxidised C10S, C15A arsenate reductase from pI258==
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The line below this paragraph, containing "STRUCTURE_1jfv", creates the "Structure Box" on the page.
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<StructureSection load='1jfv' size='340' side='right'caption='[[1jfv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JFV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LCP:PERCHLORATE+ION'>LCP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1jfv| PDB=1jfv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfv OCA], [https://pdbe.org/1jfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jfv RCSB], [https://www.ebi.ac.uk/pdbsum/1jfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARSC_STAAU ARSC_STAAU] Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.[HAMAP-Rule:MF_01624]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/1jfv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jfv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Arsenate reductase (ArsC) from Staphylococcus aureus plasmid pI258 plays a role in bacterial heavy metal resistance and catalyzes the reduction of arsenate to arsenite. The structures of the oxidized and reduced forms of ArsC were solved. ArsC has the PTPase I fold typical for low molecular weight tyrosine phosphatases (LMW PTPases). Remarkably, kinetic experiments show that pI258 ArsC also catalyzes the tyrosine phosphatase reaction in addition to arsenate reduction. These results provide evidence that ArsC from pI258 evolved from LMW PTPase by the grafting of a redox function onto a pre-existing catalytic site and that its evolutionary origin is different from those of arsenate reductases from Escherichia coli plasmid R773 and from Saccharomyces cerevisiae. The mechanism proposed here for the catalysis of arsenate reduction by pI258 ArsC involves a nucleophilic attack by Cys 10 on arsenate, the formation of a covalent intermediate and the transport of oxidative equivalents by a disulfide cascade. The reaction is associated with major structural changes in the ArsC.
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===X-Ray Structure of oxidised C10S, C15A arsenate reductase from pI258===
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Arsenate reductase from S. aureus plasmid pI258 is a phosphatase drafted for redox duty.,Zegers I, Martins JC, Willem R, Wyns L, Messens J Nat Struct Biol. 2001 Oct;8(10):843-7. PMID:11573087<ref>PMID:11573087</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1jfv" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11573087}}, adds the Publication Abstract to the page
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*[[Arsenate reductase 3D structures|Arsenate reductase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11573087 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11573087}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1JFV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFV OCA].
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==Reference==
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Arsenate reductase from S. aureus plasmid pI258 is a phosphatase drafted for redox duty., Zegers I, Martins JC, Willem R, Wyns L, Messens J, Nat Struct Biol. 2001 Oct;8(10):843-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11573087 11573087]
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[[Category: Single protein]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Martins, J C.]]
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[[Category: Martins JC]]
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[[Category: Messens, J.]]
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[[Category: Messens J]]
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[[Category: Willem, R.]]
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[[Category: Willem R]]
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[[Category: Wyns, L.]]
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[[Category: Wyns L]]
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[[Category: Zegers, I.]]
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[[Category: Zegers I]]
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[[Category: Arsenate reductase]]
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[[Category: Oxidised]]
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[[Category: Perchlorate]]
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[[Category: Potassium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:11:10 2008''
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Current revision

X-Ray Structure of oxidised C10S, C15A arsenate reductase from pI258

PDB ID 1jfv

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