1jhn

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{{Seed}}
 
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[[Image:1jhn.png|left|200px]]
 
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==Crystal Structure of the Lumenal Domain of Calnexin==
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The line below this paragraph, containing "STRUCTURE_1jhn", creates the "Structure Box" on the page.
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<StructureSection load='1jhn' size='340' side='right'caption='[[1jhn]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jhn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JHN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1jhn| PDB=1jhn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhn OCA], [https://pdbe.org/1jhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jhn RCSB], [https://www.ebi.ac.uk/pdbsum/1jhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhn ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of the Lumenal Domain of Calnexin===
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== Function ==
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[https://www.uniprot.org/uniprot/CALX_CANLF CALX_CANLF] Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11583625}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11583625 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/1jhn_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11583625}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1JHN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHN OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jhn ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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The Structure of calnexin, an ER chaperone involved in quality control of protein folding., Schrag JD, Bergeron JJ, Li Y, Borisova S, Hahn M, Thomas DY, Cygler M, Mol Cell. 2001 Sep;8(3):633-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11583625 11583625]
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</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bergeron, J M.]]
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[[Category: Bergeron JM]]
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[[Category: Borisova, S.]]
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[[Category: Borisova S]]
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[[Category: Cygler, M.]]
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[[Category: Cygler M]]
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[[Category: Hahn, M.]]
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[[Category: Hahn M]]
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[[Category: Li, Y.]]
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[[Category: Li Y]]
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[[Category: Schrag, J D.]]
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[[Category: Schrag JD]]
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[[Category: Thomas, D Y.]]
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[[Category: Thomas DY]]
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[[Category: Beta sandwich]]
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[[Category: Jelly-roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:15:37 2008''
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Current revision

Crystal Structure of the Lumenal Domain of Calnexin

PDB ID 1jhn

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