1jik

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{{Seed}}
 
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[[Image:1jik.png|left|200px]]
 
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==Crystal structure of S. aureus TyrRS in complex with SB-243545==
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The line below this paragraph, containing "STRUCTURE_1jik", creates the "Structure Box" on the page.
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<StructureSection load='1jik' size='340' side='right'caption='[[1jik]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JIK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=545:[2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]-(1,3,4,5-TETRAHYDROXY-4-HYDROXYMETHYL-PIPERIDIN-2-YL)-+ACETIC+ACID+BUTYL+ESTER'>545</scene></td></tr>
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{{STRUCTURE_1jik| PDB=1jik | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jik OCA], [https://pdbe.org/1jik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jik RCSB], [https://www.ebi.ac.uk/pdbsum/1jik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jik ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYY_STAAE SYY_STAAE] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).[HAMAP-Rule:MF_02006]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/1jik_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jik ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of S. aureus TyrRS in complex with SB-243545===
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11567092}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11567092 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11567092}}
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==About this Structure==
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1JIK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIK OCA].
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==Reference==
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Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors., Qiu X, Janson CA, Smith WW, Green SM, McDevitt P, Johanson K, Carter P, Hibbs M, Lewis C, Chalker A, Fosberry A, Lalonde J, Berge J, Brown P, Houge-Frydrych CS, Jarvest RL, Protein Sci. 2001 Oct;10(10):2008-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11567092 11567092]
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[[Category: Single protein]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Janson CA]]
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[[Category: Janson, C A.]]
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[[Category: Jarvest RL]]
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[[Category: Jarvest, R L.]]
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[[Category: Qiu X]]
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[[Category: Qiu, X.]]
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[[Category: Smith WW]]
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[[Category: Smith, W W.]]
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[[Category: Staphylococcus aureus]]
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[[Category: Structure based inhibitor design]]
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[[Category: Truncation]]
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[[Category: Tyrosyl-trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:18:02 2008''
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Current revision

Crystal structure of S. aureus TyrRS in complex with SB-243545

PDB ID 1jik

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