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1jog

From Proteopedia

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{{Seed}}
 
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[[Image:1jog.png|left|200px]]
 
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==Structure of HI0074 from Heamophilus Influenzae reveals the fold of a substrate binding domain of a nucleotidyltransferase==
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The line below this paragraph, containing "STRUCTURE_1jog", creates the "Structure Box" on the page.
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<StructureSection load='1jog' size='340' side='right'caption='[[1jog]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jog]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JOG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1jog| PDB=1jog | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jog OCA], [https://pdbe.org/1jog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jog RCSB], [https://www.ebi.ac.uk/pdbsum/1jog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jog ProSAT]</span></td></tr>
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</table>
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===Structure of HI0074 from Heamophilus Influenzae reveals the fold of a substrate binding domain of a nucleotidyltransferase===
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== Function ==
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[https://www.uniprot.org/uniprot/HEPT_HAEIN HEPT_HAEIN] Probable toxic component of a type VII toxin-antitoxin (TA) system, probably an RNase. Neutralized by cognate antitoxin MntA. Neutralization is probably due to AMPylation by MntA (Probable). A mixture of HepT and MntA binds nucleotides; the highest affinity is for TTP, ATP binds more tightly than ADP or AMP (PubMed:16028221).<ref>PMID:16028221</ref> <ref>PMID:29555683</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12486719}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12486719 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jo/1jog_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12486719}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1JOG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOG OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jog ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The HI0073/HI0074 protein pair from Haemophilus influenzae is a member of a new nucleotidyltransferase family: structure, sequence analyses, and solution studies., Lehmann C, Lim K, Chalamasetty VR, Krajewski W, Melamud E, Galkin A, Howard A, Kelman Z, Reddy PT, Murzin AG, Herzberg O, Proteins. 2003 Feb 1;50(2):249-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12486719 12486719]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Herzberg, O.]]
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[[Category: Herzberg O]]
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[[Category: Lehmann, C.]]
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[[Category: Lehmann C]]
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[[Category: Lim, K.]]
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[[Category: Lim K]]
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[[Category: S2F, Structure 2.Function Project.]]
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[[Category: Hi0074]]
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[[Category: Hypothetical protein]]
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[[Category: S2f]]
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[[Category: Structural genomic]]
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[[Category: Structure 2 function project]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:33:16 2008''
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Current revision

Structure of HI0074 from Heamophilus Influenzae reveals the fold of a substrate binding domain of a nucleotidyltransferase

PDB ID 1jog

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