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1jpm

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{{Seed}}
 
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[[Image:1jpm.png|left|200px]]
 
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==L-Ala-D/L-Glu Epimerase==
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The line below this paragraph, containing "STRUCTURE_1jpm", creates the "Structure Box" on the page.
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<StructureSection load='1jpm' size='340' side='right'caption='[[1jpm]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jpm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1jpm| PDB=1jpm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpm OCA], [https://pdbe.org/1jpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jpm RCSB], [https://www.ebi.ac.uk/pdbsum/1jpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpm ProSAT]</span></td></tr>
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</table>
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===L-Ala-D/L-Glu Epimerase===
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== Function ==
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[https://www.uniprot.org/uniprot/AEEP_BACSU AEEP_BACSU] Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has probably a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of the other Ala-X dipeptides L-Ala-L-Asp, L-Ala-L-Leu, L-Ala-L-Met, and L-Ala-L-Ser. Is not able to epimerize other L-Ala-X dipeptides. Is also active with L-Ser-L-Glu and, oddly, L-Pro-L-Glu, but not with L-Glu-L-Glu, L-Lys-L-Glu, L-Lys-L-Ala, or D-Ala-D-Ala.<ref>PMID:11747447</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11747448}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11747448 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jpm_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11747448}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1JPM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPM OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jpm ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis., Gulick AM, Schmidt DM, Gerlt JA, Rayment I, Biochemistry. 2001 Dec 25;40(51):15716-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11747448 11747448]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gerlt, J A.]]
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[[Category: Gerlt JA]]
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[[Category: Gulick, A M.]]
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[[Category: Gulick AM]]
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[[Category: Rayment, I.]]
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[[Category: Rayment I]]
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[[Category: Schmidt, D M.Z.]]
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[[Category: Schmidt DMZ]]
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[[Category: Alpha-beta barrel]]
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[[Category: Enolase superfamily]]
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[[Category: Muconate lactonizing subgroup]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:36:13 2008''
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Current revision

L-Ala-D/L-Glu Epimerase

PDB ID 1jpm

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