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1jqj

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{{Seed}}
 
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[[Image:1jqj.png|left|200px]]
 
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==Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of the beta-delta complex==
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The line below this paragraph, containing "STRUCTURE_1jqj", creates the "Structure Box" on the page.
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<StructureSection load='1jqj' size='340' side='right'caption='[[1jqj]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jqj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqj OCA], [https://pdbe.org/1jqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqj RCSB], [https://www.ebi.ac.uk/pdbsum/1jqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqj ProSAT]</span></td></tr>
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{{STRUCTURE_1jqj| PDB=1jqj | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jqj ConSurf].
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<div style="clear:both"></div>
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===Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of the beta-delta complex===
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11525728}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11525728 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11525728}}
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==About this Structure==
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1JQJ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQJ OCA].
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==Reference==
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Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III., Jeruzalmi D, Yurieva O, Zhao Y, Young M, Stewart J, Hingorani M, O'Donnell M, Kuriyan J, Cell. 2001 Aug 24;106(4):417-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11525728 11525728]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Donnell, M O.]]
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[[Category: Hingorani M]]
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[[Category: Hingorani, M.]]
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[[Category: Jeruzalmi D]]
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[[Category: Jeruzalmi, D.]]
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[[Category: Kuriyan J]]
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[[Category: Kuriyan, J.]]
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[[Category: O'Donnell M]]
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[[Category: Stewart, J.]]
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[[Category: Stewart J]]
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[[Category: Young, M.]]
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[[Category: Young M]]
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[[Category: Yurieva, O.]]
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[[Category: Yurieva O]]
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[[Category: Zhao, Y.]]
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[[Category: Zhao Y]]
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[[Category: Aaa+ atpase]]
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[[Category: Clamp loader]]
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[[Category: Dna polymerase]]
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[[Category: Dna replication]]
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[[Category: Processivity clamp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:38:54 2008''
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Current revision

Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of the beta-delta complex

PDB ID 1jqj

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