1jso

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{{Seed}}
 
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[[Image:1jso.png|left|200px]]
 
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==STRUCTURE OF AVIAN H5 HAEMAGGLUTININ BOUND TO LSTC RECEPTOR ANALOG==
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The line below this paragraph, containing "STRUCTURE_1jso", creates the "Structure Box" on the page.
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<StructureSection load='1jso' size='340' side='right'caption='[[1jso]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jso]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JSO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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{{STRUCTURE_1jso| PDB=1jso | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jso OCA], [https://pdbe.org/1jso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jso RCSB], [https://www.ebi.ac.uk/pdbsum/1jso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jso ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A5Z226_I97A2 A5Z226_I97A2] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013828_004_327643]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1jso_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jso ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF AVIAN H5 HAEMAGGLUTININ BOUND TO LSTC RECEPTOR ANALOG===
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==See Also==
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11562490}}, adds the Publication Abstract to the page
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[[Category: Influenza A virus]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11562490 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Ha Y]]
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{{ABSTRACT_PUBMED_11562490}}
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[[Category: Skehel JJ]]
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[[Category: Stevens DJ]]
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==About this Structure==
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[[Category: Wiley DC]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSO OCA].
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==Reference==
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X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11181-6. Epub 2001 Sep 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11562490 11562490]
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[[Category: Ha, Y.]]
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[[Category: Skehel, J J.]]
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[[Category: Stevens, D J.]]
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[[Category: Wiley, D C.]]
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[[Category: Fusion protein]]
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[[Category: Influenza]]
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[[Category: Receptor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:44:32 2008''
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Current revision

STRUCTURE OF AVIAN H5 HAEMAGGLUTININ BOUND TO LSTC RECEPTOR ANALOG

PDB ID 1jso

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