1jsz

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{{Seed}}
 
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[[Image:1jsz.png|left|200px]]
 
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==Crystal Structure Analysis of N7,9-dimethylguanine-VP39 complex==
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The line below this paragraph, containing "STRUCTURE_1jsz", creates the "Structure Box" on the page.
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<StructureSection load='1jsz' size='340' side='right'caption='[[1jsz]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JSZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDM:7,9-DIMETHYLGUANINE'>NDM</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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{{STRUCTURE_1jsz| PDB=1jsz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsz OCA], [https://pdbe.org/1jsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jsz RCSB], [https://www.ebi.ac.uk/pdbsum/1jsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jsz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCE_VACCW MCE_VACCW] Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase VP55 that creates mRNA's poly(A) tail. In the presence of VP39, VP55 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.<ref>PMID:1313572</ref> <ref>PMID:1670500</ref> <ref>PMID:12359447</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1jsz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jsz ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure Analysis of N7,9-dimethylguanine-VP39 complex===
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==See Also==
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*[[Poly(A) polymerase 3D structures|Poly(A) polymerase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12056899}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12056899 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12056899}}
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==About this Structure==
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1JSZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSZ OCA].
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==Reference==
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The "cap-binding slot" of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap., Hu G, Oguro A, Li C, Gershon PD, Quiocho FA, Biochemistry. 2002 Jun 18;41(24):7677-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12056899 12056899]
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[[Category: Polynucleotide adenylyltransferase]]
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[[Category: Single protein]]
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[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: Gershon, P D.]]
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[[Category: Gershon PD]]
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[[Category: Hu, G.]]
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[[Category: Hu G]]
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[[Category: Oguro, A.]]
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[[Category: Oguro A]]
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[[Category: Quiocho, F A.]]
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[[Category: Quiocho FA]]
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[[Category: Methyltransferase]]
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[[Category: Mrna cap-binding protein]]
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[[Category: Vp39]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:45:24 2008''
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Current revision

Crystal Structure Analysis of N7,9-dimethylguanine-VP39 complex

PDB ID 1jsz

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