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1jus

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{{Seed}}
 
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[[Image:1jus.png|left|200px]]
 
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<!--
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==Crystal structure of the multidrug binding transcriptional repressor QacR bound to rhodamine 6G==
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The line below this paragraph, containing "STRUCTURE_1jus", creates the "Structure Box" on the page.
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<StructureSection load='1jus' size='340' side='right'caption='[[1jus]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jus]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=RHQ:RHODAMINE+6G'>RHQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1jus| PDB=1jus | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jus OCA], [https://pdbe.org/1jus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jus RCSB], [https://www.ebi.ac.uk/pdbsum/1jus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jus ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the multidrug binding transcriptional repressor QacR bound to rhodamine 6G===
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== Function ==
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[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11739955}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11739955 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1jus_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11739955}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1JUS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jus ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural mechanisms of QacR induction and multidrug recognition., Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG, Science. 2001 Dec 7;294(5549):2158-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11739955 11739955]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Brennan, R G.]]
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[[Category: Brennan RG]]
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[[Category: Brown, M H.]]
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[[Category: Brown MH]]
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[[Category: Grkovic, S.]]
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[[Category: Grkovic S]]
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[[Category: Miller, M C.]]
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[[Category: Miller MC]]
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[[Category: Schumacher, M A.]]
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[[Category: Schumacher MA]]
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[[Category: Skurray, R A.]]
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[[Category: Skurray RA]]
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[[Category: Cationic lipophilic drug]]
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[[Category: Multidrug recognition]]
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[[Category: Qacr]]
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[[Category: Rhodamine 6g]]
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[[Category: S. aureus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:55:58 2008''
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Current revision

Crystal structure of the multidrug binding transcriptional repressor QacR bound to rhodamine 6G

PDB ID 1jus

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