1jyh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:42, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1jyh.png|left|200px]]
 
-
<!--
+
==Crystal Structure of the Escherichia coli SbmC protein (AKA Gyrase Inhibitory Protein GyrI, AKA YeeB)==
-
The line below this paragraph, containing "STRUCTURE_1jyh", creates the "Structure Box" on the page.
+
<StructureSection load='1jyh' size='340' side='right'caption='[[1jyh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1jyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyh OCA], [https://pdbe.org/1jyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jyh RCSB], [https://www.ebi.ac.uk/pdbsum/1jyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyh ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1jyh TOPSAN]</span></td></tr>
-
{{STRUCTURE_1jyh| PDB=1jyh | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===Crystal Structure of the Escherichia coli SbmC protein (AKA Gyrase Inhibitory Protein GyrI, AKA YeeB)===
+
[https://www.uniprot.org/uniprot/SBMC_ECOLI SBMC_ECOLI] Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protecting cells against DNA damage.<ref>PMID:11850398</ref> <ref>PMID:13680098</ref> <ref>PMID:8709849</ref> <ref>PMID:9442027</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==About this Structure==
+
Check<jmol>
-
1JYH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYH OCA].
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jyh_consurf.spt"</scriptWhenChecked>
-
==Reference==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
Crystal structure of the Escherichia coli SbmC protein that protects cells from the DNA replication inhibitor microcin B17., Romanowski MJ, Gibney SA, Burley SK, Proteins. 2002 May 15;47(3):403-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11948793 11948793]
+
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jyh ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Burley, S K.]]
+
[[Category: Burley SK]]
-
[[Category: Gibney, S A.]]
+
[[Category: Gibney SA]]
-
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
+
[[Category: Romanowski MJ]]
-
[[Category: Romanowski, M J.]]
+
-
[[Category: Gyrase inhibitor]]
+
-
[[Category: New york structural genomix research consortium]]
+
-
[[Category: Nysgxrc]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi]]
+
-
[[Category: Structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:06:12 2008''
+

Current revision

Crystal Structure of the Escherichia coli SbmC protein (AKA Gyrase Inhibitory Protein GyrI, AKA YeeB)

PDB ID 1jyh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jyh"
Personal tools