1jyo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (04:39, 17 October 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1jyo.png|left|200px]]
 
-
<!--
+
==Structure of the Salmonella Virulence Effector SptP in Complex with its Secretion Chaperone SicP==
-
The line below this paragraph, containing "STRUCTURE_1jyo", creates the "Structure Box" on the page.
+
<StructureSection load='1jyo' size='340' side='right'caption='[[1jyo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1jyo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyo OCA], [https://pdbe.org/1jyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jyo RCSB], [https://www.ebi.ac.uk/pdbsum/1jyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyo ProSAT]</span></td></tr>
-
{{STRUCTURE_1jyo| PDB=1jyo | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SICP_SALTY SICP_SALTY] Molecular chaperone required for sptP stabilization and secretion.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Many bacterial pathogens use a type III protein secretion system to deliver virulence effector proteins directly into the host cell cytosol, where they modulate cellular processes. A requirement for the effective translocation of several such effector proteins is the binding of specific cytosolic chaperones, which typically interact with discrete domains in the virulence factors. We report here the crystal structure at 1.9 A resolution of the chaperone-binding domain of the Salmonella effector protein SptP with its cognate chaperone SicP. The structure reveals that this domain is maintained in an extended, unfolded conformation that is wound around three successive chaperone molecules. Short segments from two different SptP molecules are juxtaposed by the chaperones, where they dimerize across a hydrophobic interface. These results imply that the chaperones associated with the type III secretion system maintain their substrates in a secretion-competent state that is capable of engaging the secretion machinery to travel through the type III apparatus in an unfolded or partially folded manner.
-
===Structure of the Salmonella Virulence Effector SptP in Complex with its Secretion Chaperone SicP===
+
Maintenance of an unfolded polypeptide by a cognate chaperone in bacterial type III secretion.,Stebbins CE, Galan JE Nature. 2001 Nov 1;414(6859):77-81. PMID:11689946<ref>PMID:11689946</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1jyo" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_11689946}}, adds the Publication Abstract to the page
+
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 11689946 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_11689946}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1JYO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYO OCA].
+
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-
 
+
[[Category: Galan JE]]
-
==Reference==
+
[[Category: Stebbins CE]]
-
Maintenance of an unfolded polypeptide by a cognate chaperone in bacterial type III secretion., Stebbins CE, Galan JE, Nature. 2001 Nov 1;414(6859):77-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11689946 11689946]
+
-
[[Category: Protein complex]]
+
-
[[Category: Salmonella typhimurium]]
+
-
[[Category: Galan, J E.]]
+
-
[[Category: Stebbins, C E.]]
+
-
[[Category: Bacterial pathogenesis]]
+
-
[[Category: Chaperone]]
+
-
[[Category: Infectious disease]]
+
-
[[Category: Protein folding]]
+
-
[[Category: Salmonella]]
+
-
[[Category: Sicp]]
+
-
[[Category: Sptp]]
+
-
[[Category: Type iii secretion]]
+
-
[[Category: Unfolded]]
+
-
[[Category: Virulence factor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:07:46 2008''
+

Current revision

Structure of the Salmonella Virulence Effector SptP in Complex with its Secretion Chaperone SicP

PDB ID 1jyo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jyo"
Personal tools