1k0n

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{{Seed}}
 
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[[Image:1k0n.png|left|200px]]
 
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==Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione==
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The line below this paragraph, containing "STRUCTURE_1k0n", creates the "Structure Box" on the page.
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<StructureSection load='1k0n' size='340' side='right'caption='[[1k0n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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{{STRUCTURE_1k0n| PDB=1k0n | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0n OCA], [https://pdbe.org/1k0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0n RCSB], [https://www.ebi.ac.uk/pdbsum/1k0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0n ConSurf].
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<div style="clear:both"></div>
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===Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione===
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11551966 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11551966}}
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==About this Structure==
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1K0N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0N OCA].
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==Reference==
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Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution., Harrop SJ, DeMaere MZ, Fairlie WD, Reztsova T, Valenzuela SM, Mazzanti M, Tonini R, Qiu MR, Jankova L, Warton K, Bauskin AR, Wu WM, Pankhurst S, Campbell TJ, Breit SN, Curmi PM, J Biol Chem. 2001 Nov 30;276(48):44993-5000. Epub 2001 Sep 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11551966 11551966]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bauskin, A R.]]
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[[Category: Bauskin AR]]
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[[Category: Breit, S N.]]
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[[Category: Breit SN]]
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[[Category: Campbell, T J.]]
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[[Category: Campbell TJ]]
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[[Category: Curmi, P M.G.]]
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[[Category: Curmi PMG]]
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[[Category: DeMaere, M Z.]]
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[[Category: DeMaere MZ]]
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[[Category: Fairlie, W D.]]
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[[Category: Fairlie WD]]
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[[Category: Harrop, S J.]]
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[[Category: Harrop SJ]]
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[[Category: Jankova, L.]]
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[[Category: Jankova L]]
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[[Category: Mazzanti, M.]]
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[[Category: Mazzanti M]]
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[[Category: Pankhurst, S.]]
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[[Category: Pankhurst S]]
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[[Category: Qiu, M R.]]
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[[Category: Qiu MR]]
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[[Category: Reztsova, T.]]
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[[Category: Reztsova T]]
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[[Category: Tonini, R.]]
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[[Category: Tonini R]]
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[[Category: Valenzuela, S M.]]
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[[Category: Valenzuela SM]]
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[[Category: Warton, K.]]
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[[Category: Warton K]]
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[[Category: Wu, W M.]]
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[[Category: Wu WM]]
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[[Category: Chloride ion channel]]
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[[Category: Clic1]]
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[[Category: Glutathione]]
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[[Category: Glutathione-s-tranferase superfamily]]
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[[Category: Ncc27]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:11:56 2008''
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Current revision

Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione

PDB ID 1k0n

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