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1hmd

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(New page: 200px<br /><applet load="1hmd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hmd, resolution 2.0&Aring;" /> '''THE STRUCTURE OF DEOX...)
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[[Image:1hmd.gif|left|200px]]<br /><applet load="1hmd" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hmd, resolution 2.0&Aring;" />
 
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'''THE STRUCTURE OF DEOXY AND OXY HEMERYTHRIN AT 2.0 ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==THE STRUCTURE OF DEOXY AND OXY HEMERYTHRIN AT 2.0 ANGSTROMS RESOLUTION==
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The crystallographic structure analyses of deoxy and oxy hemerythrin have, been carried out at 2.0 A resolution to extend the low resolution views of, the physiological forms of this oxygen-binding protein. Restrained, least-squares refinement has produced molecular models giving R-values of, 16.8% for deoxy (41,064 reflections from 10 A to 2.0 A) and 17.3% for oxy, hemerythrin (40,413 reflections from 10.0 A to 2.0 A). The protein, structure in each derivative is very similar to that of myohemerythrin and, the various met forms of hemerythrin. The binuclear complex in each, derivative retains an oxygen atom bridging the two iron atoms, but the, bond lengths found in deoxy hemerythrin support the idea that, in that, form, the bridge is protonated, i.e. the bridging group is a hydroxyl., Dioxygen binds to the pentaco-ordinate iron atom in deoxy hemerythrin in, the conversion to oxy hemerythrin. The interatomic distances are, consistent with the proposed mechanism where the proton from the bridging, group is transferred to the bound dioxygen, stabilizing it in the peroxo, oxidation state by forming a hydrogen bond between the peroxy group and, the bridging oxygen atom.
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<StructureSection load='1hmd' size='340' side='right'caption='[[1hmd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1hmd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Themiste_dyscritum Themiste dyscritum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HMD FirstGlance]. <br>
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1HMD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Themiste_dyscritum Themiste dyscritum] with ACE and FEO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HMD OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmd OCA], [https://pdbe.org/1hmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hmd RCSB], [https://www.ebi.ac.uk/pdbsum/1hmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hmd ProSAT]</span></td></tr>
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Structures of deoxy and oxy hemerythrin at 2.0 A resolution., Holmes MA, Le Trong I, Turley S, Sieker LC, Stenkamp RE, J Mol Biol. 1991 Apr 5;218(3):583-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2016748 2016748]
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</table>
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[[Category: Single protein]]
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== Function ==
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[https://www.uniprot.org/uniprot/HEMT_THEDY HEMT_THEDY] Hemerythrin is a respiratory protein in blood cells of certain marine worms. The oxygen-binding site in each chain contains two iron atoms.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/1hmd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hmd ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Themiste dyscritum]]
[[Category: Themiste dyscritum]]
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[[Category: Holmes, M.A.]]
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[[Category: Holmes MA]]
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[[Category: Letrong, I.]]
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[[Category: Letrong I]]
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[[Category: Sieker, L.C.]]
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[[Category: Sieker LC]]
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[[Category: Stenkamp, R.E.]]
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[[Category: Stenkamp RE]]
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[[Category: Turley, S.]]
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[[Category: Turley S]]
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[[Category: ACE]]
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[[Category: FEO]]
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[[Category: oxygen transport]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:39:11 2007''
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Current revision

THE STRUCTURE OF DEOXY AND OXY HEMERYTHRIN AT 2.0 ANGSTROMS RESOLUTION

PDB ID 1hmd

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