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1k4r

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{{Seed}}
 
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[[Image:1k4r.png|left|200px]]
 
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==Structure of Dengue Virus==
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The line below this paragraph, containing "STRUCTURE_1k4r", creates the "Structure Box" on the page.
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<SX load='1k4r' size='340' side='right' viewer='molstar' caption='[[1k4r]], [[Resolution|resolution]] 24.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k4r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chimeric_Tick-borne_encephalitis_virus/Dengue_virus_4 Chimeric Tick-borne encephalitis virus/Dengue virus 4]. The July 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K4R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 24&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k4r OCA], [https://pdbe.org/1k4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k4r RCSB], [https://www.ebi.ac.uk/pdbsum/1k4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k4r ProSAT]</span></td></tr>
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{{STRUCTURE_1k4r| PDB=1k4r | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C3V005_9FLAV C3V005_9FLAV]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/1k4r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k4r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.
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===Structure of Dengue Virus===
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Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.,Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH Cell. 2002 Mar 8;108(5):717-25. PMID:11893341<ref>PMID:11893341</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11893341}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1k4r" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11893341 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_11893341}}
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__TOC__
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</SX>
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==About this Structure==
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[[Category: Chimeric Tick-borne encephalitis virus/Dengue virus 4]]
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1K4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA].
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[[Category: Dengue Virus]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: RCSB PDB Molecule of the Month]]
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Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11893341 11893341]
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[[Category: Baker TS]]
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[[Category: Single protein]]
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[[Category: Chipman PR]]
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[[Category: Tick-borne encephalitis virus]]
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[[Category: Corver J]]
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[[Category: Baker, T S.]]
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[[Category: Jones CT]]
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[[Category: Chipman, P R.]]
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[[Category: Kuhn RJ]]
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[[Category: Corver, J.]]
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[[Category: Lenches E]]
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[[Category: Jones, C T.]]
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[[Category: Mukhopadhyay S]]
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[[Category: Kuhn, R J.]]
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[[Category: Pletnev SV]]
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[[Category: Lenches, E.]]
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[[Category: Rossmann MG]]
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[[Category: Mukhopadhyay, S.]]
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[[Category: Strauss EG]]
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[[Category: Pletnev, S V.]]
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[[Category: Strauss JH]]
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[[Category: Rossmann, M G.]]
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[[Category: Zhang W]]
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[[Category: Strauss, E G.]]
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[[Category: Strauss, J H.]]
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[[Category: Zhang, W.]]
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[[Category: Dengue virus]]
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[[Category: Flaviviridae]]
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[[Category: Flavivirus]]
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[[Category: Glycoprotein e from tick-borne encephalitis virus]]
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[[Category: Icosahedral virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:46:24 2008''
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Current revision

Structure of Dengue Virus

1k4r, resolution 24.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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