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1k5h

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{{Seed}}
 
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[[Image:1k5h.png|left|200px]]
 
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==1-deoxy-D-xylulose-5-phosphate reductoisomerase==
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The line below this paragraph, containing "STRUCTURE_1k5h", creates the "Structure Box" on the page.
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<StructureSection load='1k5h' size='340' side='right'caption='[[1k5h]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k5h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K5H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k5h OCA], [https://pdbe.org/1k5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k5h RCSB], [https://www.ebi.ac.uk/pdbsum/1k5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k5h ProSAT]</span></td></tr>
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{{STRUCTURE_1k5h| PDB=1k5h | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DXR_ECOLI DXR_ECOLI] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/1k5h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k5h ConSurf].
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<div style="clear:both"></div>
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===1-deoxy-D-xylulose-5-phosphate reductoisomerase===
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==See Also==
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*[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11741911}}, adds the Publication Abstract to the page
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[[Category: Escherichia coli K-12]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11741911 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Beck E]]
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{{ABSTRACT_PUBMED_11741911}}
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[[Category: Hintz M]]
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[[Category: Jomaa H]]
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==About this Structure==
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[[Category: Klebe G]]
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1K5H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5H OCA].
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[[Category: Reuter K]]
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[[Category: Sanderbrand S]]
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==Reference==
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[[Category: Steinbrecher I]]
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Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis., Reuter K, Sanderbrand S, Jomaa H, Wiesner J, Steinbrecher I, Beck E, Hintz M, Klebe G, Stubbs MT, J Biol Chem. 2002 Feb 15;277(7):5378-84. Epub 2001 Dec 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11741911 11741911]
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[[Category: Stubbs MT]]
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[[Category: Escherichia coli]]
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[[Category: Wiesner J]]
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[[Category: Single protein]]
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[[Category: Beck, E.]]
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[[Category: Hintz, M.]]
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[[Category: Jomaa, H.]]
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[[Category: Klebe, G.]]
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[[Category: Reuter, K.]]
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[[Category: Sanderbrand, S.]]
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[[Category: Steinbrecher, I.]]
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[[Category: Stubbs, M T.]]
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[[Category: Wiesner, J.]]
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[[Category: Alpha-helix]]
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[[Category: Beta-barrel]]
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[[Category: Dinucleotide binding motif]]
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[[Category: Induced fit]]
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[[Category: Variable loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:48:57 2008''
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Current revision

1-deoxy-D-xylulose-5-phosphate reductoisomerase

PDB ID 1k5h

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