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1k9r

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{{Seed}}
 
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[[Image:1k9r.png|left|200px]]
 
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<!--
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==YAP65 WW domain complexed to Acetyl-PLPPY==
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The line below this paragraph, containing "STRUCTURE_1k9r", creates the "Structure Box" on the page.
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<StructureSection load='1k9r' size='340' side='right'caption='[[1k9r]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k9r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K9R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_1k9r| PDB=1k9r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9r OCA], [https://pdbe.org/1k9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k9r RCSB], [https://www.ebi.ac.uk/pdbsum/1k9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k9r ProSAT]</span></td></tr>
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</table>
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===YAP65 WW domain complexed to Acetyl-PLPPY===
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== Function ==
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[https://www.uniprot.org/uniprot/YAP1_HUMAN YAP1_HUMAN] Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).<ref>PMID:12807903</ref> <ref>PMID:17974916</ref> <ref>PMID:18579750</ref> <ref>PMID:18158288</ref> <ref>PMID:18280240</ref> <ref>PMID:21364637</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11743730}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11743730 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/1k9r_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11743730}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1K9R is a [[Protein complex]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9R OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k9r ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope., Pires JR, Taha-Nejad F, Toepert F, Ast T, Hoffmuller U, Schneider-Mergener J, Kuhne R, Macias MJ, Oschkinat H, J Mol Biol. 2001 Dec 14;314(5):1147-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11743730 11743730]
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<references/>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Ast, T.]]
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</StructureSection>
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[[Category: Hoffmuller, U.]]
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[[Category: Homo sapiens]]
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[[Category: Kuhne, R.]]
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[[Category: Large Structures]]
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[[Category: Macias, M J.]]
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[[Category: Ast T]]
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[[Category: Oschkinat, H.]]
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[[Category: Hoffmuller U]]
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[[Category: Pires, J R.]]
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[[Category: Kuhne R]]
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[[Category: Schneider-Mergener, J.]]
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[[Category: Macias MJ]]
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[[Category: Taha-Nejad, F.]]
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[[Category: Oschkinat H]]
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[[Category: Toepert, F.]]
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[[Category: Pires JR]]
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[[Category: Beta-sheet protein]]
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[[Category: Schneider-Mergener J]]
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[[Category: Ligand]]
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[[Category: Taha-Nejad F]]
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[[Category: Proline-rich peptide]]
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[[Category: Toepert F]]
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[[Category: Ww domain]]
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[[Category: Yap65]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:00:08 2008''
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Current revision

YAP65 WW domain complexed to Acetyl-PLPPY

PDB ID 1k9r

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