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1kaz

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{{Seed}}
 
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[[Image:1kaz.png|left|200px]]
 
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==70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71E MUTANT==
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The line below this paragraph, containing "STRUCTURE_1kaz", creates the "Structure Box" on the page.
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<StructureSection load='1kaz' size='340' side='right'caption='[[1kaz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kaz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KAZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1kaz| PDB=1kaz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kaz OCA], [https://pdbe.org/1kaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kaz RCSB], [https://www.ebi.ac.uk/pdbsum/1kaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kaz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/1kaz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kaz ConSurf].
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<div style="clear:both"></div>
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===70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71E MUTANT===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8663302}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8663302 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8663302}}
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==About this Structure==
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1KAZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KAZ OCA].
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==Reference==
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Lysine 71 of the chaperone protein Hsc70 Is essential for ATP hydrolysis., O'Brien MC, Flaherty KM, McKay DB, J Biol Chem. 1996 Jul 5;271(27):15874-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8663302 8663302]
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[[Category: Adenosinetriphosphatase]]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Brien, M C.O.]]
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[[Category: Flaherty KM]]
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[[Category: Flaherty, K M.]]
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[[Category: Mckay DB]]
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[[Category: Mckay, D B.]]
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[[Category: O'Brien MC]]
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[[Category: Atp-binding]]
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[[Category: Heat shock]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:03:32 2008''
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Current revision

70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71E MUTANT

PDB ID 1kaz

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