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1kbt

From Proteopedia

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{{Seed}}
 
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[[Image:1kbt.png|left|200px]]
 
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==SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 12 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1kbt", creates the "Structure Box" on the page.
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<StructureSection load='1kbt' size='340' side='right'caption='[[1kbt]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kbt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KBT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kbt OCA], [https://pdbe.org/1kbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kbt RCSB], [https://www.ebi.ac.uk/pdbsum/1kbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kbt ProSAT]</span></td></tr>
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{{STRUCTURE_1kbt| PDB=1kbt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3SA4_NAJAT 3SA4_NAJAT] Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.<ref>PMID:16407244</ref> <ref>PMID:8448165</ref> <ref>PMID:9398182</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/1kbt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kbt ConSurf].
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<div style="clear:both"></div>
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===SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 12 STRUCTURES===
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==See Also==
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*[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9398182}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9398182 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_9398182}}
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==About this Structure==
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1KBT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBT OCA].
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==Reference==
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Comparison of the hemolytic activity and solution structures of two snake venom cardiotoxin analogues which only differ in their N-terminal amino acid., Jang JY, Krishnaswamy T, Kumar S, Jayaraman G, Yang PW, Yu C, Biochemistry. 1997 Dec 2;36(48):14635-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9398182 9398182]
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[[Category: Naja atra]]
[[Category: Naja atra]]
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[[Category: Single protein]]
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[[Category: Jayaraman G]]
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[[Category: Jayaraman, G.]]
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[[Category: Jeng JY]]
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[[Category: Jeng, J Y.]]
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[[Category: Kumar TKS]]
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[[Category: Kumar, T K.S.]]
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[[Category: Yu C]]
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[[Category: Yu, C.]]
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[[Category: Cardiotoxin]]
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[[Category: Cytotoxin]]
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[[Category: Multigene family]]
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[[Category: Venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:06:00 2008''
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Current revision

SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 12 STRUCTURES

PDB ID 1kbt

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