1hq8

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(New page: 200px<br /><applet load="1hq8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hq8, resolution 1.95&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1hq8.gif|left|200px]]<br /><applet load="1hq8" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hq8, resolution 1.95&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A==
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NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory, molecule that is found on natural killer cells,T cells and activated, macrophages.The natural ligands for murine NKG2D are distant major, histocompatibility complex homologs, retinoic acid early transcript (Rae1), and H-60 minor histocompatibility antigen. The crystal structure of the, extracellular region of murine NKG2D reveals close homology with other, C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer, receptors, as well as their surface topography and electrostatic, properties.The NKG2D structure provides the first structural insights into, the role and ligand specificity of this stimulatory receptor in the innate, and adaptive immune system.
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<StructureSection load='1hq8' size='340' side='right'caption='[[1hq8]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hq8 OCA], [https://pdbe.org/1hq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1hq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hq8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NKG2D_MOUSE NKG2D_MOUSE] Receptor for RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. Involved in the immune surveillance exerted by T and B lymphocytes.<ref>PMID:12370332</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/1hq8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hq8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells,T cells and activated macrophages.The natural ligands for murine NKG2D are distant major histocompatibility complex homologs, retinoic acid early transcript (Rae1) and H-60 minor histocompatibility antigen. The crystal structure of the extracellular region of murine NKG2D reveals close homology with other C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer receptors, as well as their surface topography and electrostatic properties.The NKG2D structure provides the first structural insights into the role and ligand specificity of this stimulatory receptor in the innate and adaptive immune system.
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==About this Structure==
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Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.,Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA Nat Immunol. 2001 Mar;2(3):248-54. PMID:11224525<ref>PMID:11224525</ref>
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1HQ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A., Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA, Nat Immunol. 2001 Mar;2(3):248-54. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11224525 11224525]
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</div>
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[[Category: Mus musculus]]
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<div class="pdbe-citations 1hq8" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Bauer, S.]]
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[[Category: Busch, D.H.]]
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[[Category: Rudolph, M.G.]]
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[[Category: Teyton, L.]]
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[[Category: Villmow, B.]]
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[[Category: Wilson, I.A.]]
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[[Category: Wolan, D.W.]]
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[[Category: cis-proline]]
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[[Category: homodimer]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:44:23 2007''
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==See Also==
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*[[NK cell receptor|NK cell receptor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Bauer S]]
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[[Category: Busch DH]]
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[[Category: Rudolph MG]]
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[[Category: Teyton L]]
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[[Category: Villmow B]]
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[[Category: Wilson IA]]
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[[Category: Wolan DW]]

Current revision

CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A

PDB ID 1hq8

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