1kcu

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{{Seed}}
 
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[[Image:1kcu.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF ANTIBODY PC287==
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The line below this paragraph, containing "STRUCTURE_1kcu", creates the "Structure Box" on the page.
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<StructureSection load='1kcu' size='340' side='right'caption='[[1kcu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kcu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KCU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kcu OCA], [https://pdbe.org/1kcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kcu RCSB], [https://www.ebi.ac.uk/pdbsum/1kcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kcu ProSAT]</span></td></tr>
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{{STRUCTURE_1kcu| PDB=1kcu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/1kcu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kcu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystal structures of distinct mAbs that recognize a common epitope of a peptide Ag have been determined and analyzed in the unbound and bound forms. These Abs display dissimilar binding site structures in the absence of the Ag. The dissimilarity is primarily expressed in the conformations of complementarity-determining region H3, which is responsible for defining the epitope specificity. Interestingly, however, the three Abs exhibit similar complementarity-determining region conformations in the Ag binding site while recognizing the common epitope, indicating that different pathways of binding are used for Ag recognition. The epitope also exhibits conformational similarity when bound to each of these Abs, although the peptide Ag was otherwise flexible. The observed conformational convergence in the epitope and the Ag binding site was facilitated by the plasticity in the nature of interactions.
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===CRYSTAL STRUCTURE OF ANTIBODY PC287===
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Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response.,Nair DT, Singh K, Siddiqui Z, Nayak BP, Rao KV, Salunke DM J Immunol. 2002 Mar 1;168(5):2371-82. PMID:11859128<ref>PMID:11859128</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1kcu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11859128 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11859128}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1KCU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCU OCA].
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==Reference==
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Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response., Nair DT, Singh K, Siddiqui Z, Nayak BP, Rao KV, Salunke DM, J Immunol. 2002 Mar 1;168(5):2371-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11859128 11859128]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Nair DT]]
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[[Category: Nair, D T.]]
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[[Category: Nayak BP]]
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[[Category: Nayak, B P.]]
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[[Category: Rao KVS]]
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[[Category: Rao, K V.S.]]
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[[Category: Salunke DM]]
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[[Category: Salunke, D M.]]
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[[Category: Siddiqui Z]]
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[[Category: Siddiqui, Z.]]
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[[Category: Singh K]]
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[[Category: Singh, K.]]
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[[Category: Anti-peptide antibody]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:08:33 2008''
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Current revision

CRYSTAL STRUCTURE OF ANTIBODY PC287

PDB ID 1kcu

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