1kfu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:46, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1kfu.png|left|200px]]
 
-
<!--
+
==Crystal Structure of Human m-Calpain Form II==
-
The line below this paragraph, containing "STRUCTURE_1kfu", creates the "Structure Box" on the page.
+
<StructureSection load='1kfu' size='340' side='right'caption='[[1kfu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1kfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dkv 1dkv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KFU FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kfu OCA], [https://pdbe.org/1kfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kfu RCSB], [https://www.ebi.ac.uk/pdbsum/1kfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kfu ProSAT]</span></td></tr>
-
{{STRUCTURE_1kfu| PDB=1kfu | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CAN2_HUMAN CAN2_HUMAN] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/1kfu_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kfu ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal Structure of Human m-Calpain Form II===
+
==See Also==
-
 
+
*[[Calpain 3D structures|Calpain 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10639123}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 10639123 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_10639123}}
+
-
 
+
-
==About this Structure==
+
-
1KFU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dkv 1dkv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KFU OCA].
+
-
 
+
-
==Reference==
+
-
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium., Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W, Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):588-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10639123 10639123]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Hydrolase]]
+
[[Category: Large Structures]]
-
[[Category: Protein complex]]
+
[[Category: Bartunik H]]
-
[[Category: Bartunik, H.]]
+
[[Category: Bode W]]
-
[[Category: Bode, W.]]
+
[[Category: Bourenkow G]]
-
[[Category: Bourenkow, G.]]
+
[[Category: Braun M]]
-
[[Category: Braun, M.]]
+
[[Category: Fernandez-Catalan C]]
-
[[Category: Fernandez-Catalan, C.]]
+
[[Category: Huber R]]
-
[[Category: Huber, R.]]
+
[[Category: Irie A]]
-
[[Category: Irie, A.]]
+
[[Category: Masumoto H]]
-
[[Category: Masumoto, H.]]
+
[[Category: Nakagawa K]]
-
[[Category: Nakagawa, K.]]
+
[[Category: Sorimachi H]]
-
[[Category: Sorimachi, H.]]
+
[[Category: Strobl S]]
-
[[Category: Strobl, S.]]
+
[[Category: Suzuki K]]
-
[[Category: Suzuki, K.]]
+
-
[[Category: Calcium]]
+
-
[[Category: Papain-like]]
+
-
[[Category: Regulation]]
+
-
[[Category: Thiol-protease]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:16:55 2008''
+

Current revision

Crystal Structure of Human m-Calpain Form II

PDB ID 1kfu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kfu"
Personal tools