1ki6

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{{Seed}}
 
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[[Image:1ki6.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH A 5-IODOURACIL ANHYDROHEXITOL NUCLEOSIDE==
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The line below this paragraph, containing "STRUCTURE_1ki6", creates the "Structure Box" on the page.
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<StructureSection load='1ki6' size='340' side='right'caption='[[1ki6]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ki6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KI6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHU:1,5-ANHYDRO-2,3-DIDEOXY-2-(5-IODOURACIL-1-YL)-D-ABABINO-HEXITOL'>AHU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1ki6| PDB=1ki6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ki6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ki6 OCA], [https://pdbe.org/1ki6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ki6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ki6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ki6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1ki6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ki6 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH A 5-IODOURACIL ANHYDROHEXITOL NUCLEOSIDE===
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==See Also==
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*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9715911}}, adds the Publication Abstract to the page
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[[Category: Human alphaherpesvirus 1 strain 17]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9715911 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Bennett MS]]
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{{ABSTRACT_PUBMED_9715911}}
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[[Category: Champness JN]]
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[[Category: Herdewijn P]]
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==About this Structure==
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[[Category: Ostrowski T]]
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1KI6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI6 OCA].
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[[Category: Sanderson MR]]
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[[Category: Summers WC]]
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==Reference==
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[[Category: Wien F]]
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Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands., Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, Sanderson MR, Proteins. 1998 Aug 15;32(3):350-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9715911 9715911]
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[[Category: Human herpesvirus 1]]
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[[Category: Protein complex]]
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[[Category: Thymidine kinase]]
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[[Category: Bennett, M S.]]
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[[Category: Champness, J N.]]
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[[Category: Herdewijn, P.]]
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[[Category: Ostrowski, T.]]
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[[Category: Sanderson, M R.]]
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[[Category: Summers, W C.]]
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[[Category: Wien, F.]]
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[[Category: 5-iodouracil anhydrohexitol nucleoside]]
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[[Category: Alphaherpesvirinae]]
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[[Category: Ds-dna enveloped viruse]]
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[[Category: Herpesviridae]]
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[[Category: Phosphotransferase]]
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[[Category: Substrate analog]]
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[[Category: Thymidine kinase]]
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[[Category: Viridae]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:22:59 2008''
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Current revision

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH A 5-IODOURACIL ANHYDROHEXITOL NUCLEOSIDE

PDB ID 1ki6

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