1hsk

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(New page: 200px<br /><applet load="1hsk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hsk, resolution 2.30&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1hsk.gif|left|200px]]<br /><applet load="1hsk" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hsk, resolution 2.30&Aring;" />
 
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'''CRYSTAL STRUCTURE OF S. AUREUS MURB'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF S. AUREUS MURB==
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The X-ray crystal structure of the substrate free form of Staphylococcus, aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB) has been solved, to 2.3 A resolution with an R-factor of 20.3% and a free R-factor of, 22.3%. While the overall fold of the S. aureus enzyme is similar to that, of the homologous Escherichia coli MurB X-ray crystal structure, notable, distinctions between the S. aureus and E. coli MurB protein structures, occur in residues involved in substrate binding. Analysis of available, MurB sequences from other bacteria suggest that the S. aureus MurB, structure is representative of a distinct structural class of, UDP-N-acetylenolpyruvylglucosamine reductases including Bacillus subtilis, and Helicobacter pylori that are characterized by a modified mechanism for, substrate binding.
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<StructureSection load='1hsk' size='340' side='right'caption='[[1hsk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1hsk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HSK FirstGlance]. <br>
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1HSK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with FAD as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/UDP-N-acetylmuramate_dehydrogenase UDP-N-acetylmuramate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.158 1.1.1.158] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HSK OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hsk OCA], [https://pdbe.org/1hsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hsk RCSB], [https://www.ebi.ac.uk/pdbsum/1hsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hsk ProSAT]</span></td></tr>
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A structural variation for MurB: X-ray crystal structure of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB)., Benson TE, Harris MS, Choi GH, Cialdella JI, Herberg JT, Martin JP Jr, Baldwin ET, Biochemistry. 2001 Feb 27;40(8):2340-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11327854 11327854]
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</table>
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[[Category: Single protein]]
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== Function ==
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[https://www.uniprot.org/uniprot/MURB_STAAU MURB_STAAU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/1hsk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hsk ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: UDP-N-acetylmuramate dehydrogenase]]
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[[Category: Baldwin ET]]
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[[Category: Baldwin, E.T.]]
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[[Category: Benson TE]]
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[[Category: Benson, T.E.]]
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[[Category: Choi GH]]
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[[Category: Choi, G.H.]]
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[[Category: Cialdella JI]]
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[[Category: Cialdella, J.I.]]
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[[Category: Harris MS]]
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[[Category: Harris, M.S.]]
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[[Category: Herberg JT]]
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[[Category: Herberg, J.T.]]
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[[Category: Martin Jr JP]]
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[[Category: Jr., J.P.Martin.]]
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[[Category: FAD]]
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[[Category: cell division]]
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[[Category: cell wall]]
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[[Category: fad]]
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[[Category: flavoprotein]]
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[[Category: nadp]]
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[[Category: oxidoreductase]]
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[[Category: peptidoglycan synthesis]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:47:55 2007''
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Current revision

CRYSTAL STRUCTURE OF S. AUREUS MURB

PDB ID 1hsk

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