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1kiv

From Proteopedia

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{{Seed}}
 
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[[Image:1kiv.png|left|200px]]
 
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<!--
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==RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)==
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The line below this paragraph, containing "STRUCTURE_1kiv", creates the "Structure Box" on the page.
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<StructureSection load='1kiv' size='340' side='right'caption='[[1kiv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kiv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KIV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kiv OCA], [https://pdbe.org/1kiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kiv RCSB], [https://www.ebi.ac.uk/pdbsum/1kiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kiv ProSAT]</span></td></tr>
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{{STRUCTURE_1kiv| PDB=1kiv | SCENE= }}
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</table>
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== Function ==
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===RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)===
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[https://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_10026282}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 10026282 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1kiv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_10026282}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kiv ConSurf].
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1KIV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KIV OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance., Mochalkin I, Cheng B, Klezovitch O, Scanu AM, Tulinsky A, Biochemistry. 1999 Feb 16;38(7):1990-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10026282 10026282]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Mochalkin, I.]]
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[[Category: Mochalkin I]]
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[[Category: Scanu, A.]]
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[[Category: Scanu A]]
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[[Category: Tulinsky, A.]]
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[[Category: Tulinsky A]]
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[[Category: Kringle]]
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[[Category: Lysine binding site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:24:45 2008''
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Current revision

RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)

PDB ID 1kiv

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