1kkf

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{{Seed}}
 
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[[Image:1kkf.png|left|200px]]
 
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==Complex of E. coli Adenylosuccinate Synthetase with IMP, Hadacidin, Pyrophosphate, and Mg==
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The line below this paragraph, containing "STRUCTURE_1kkf", creates the "Structure Box" on the page.
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<StructureSection load='1kkf' size='340' side='right'caption='[[1kkf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KKF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1kkf| PDB=1kkf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkf OCA], [https://pdbe.org/1kkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kkf RCSB], [https://www.ebi.ac.uk/pdbsum/1kkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kkf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PURA_ECOLI PURA_ECOLI] Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).[HAMAP-Rule:MF_00011]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kkf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kkf ConSurf].
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<div style="clear:both"></div>
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===Complex of E. coli Adenylosuccinate Synthetase with IMP, Hadacidin, Pyrophosphate, and Mg===
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==See Also==
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*[[Adenylosuccinate synthetase 3D structures|Adenylosuccinate synthetase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11741996}}, adds the Publication Abstract to the page
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[[Category: Escherichia coli K-12]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11741996 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Fromm HJ]]
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{{ABSTRACT_PUBMED_11741996}}
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[[Category: Honzatko RB]]
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[[Category: Hou Z]]
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==About this Structure==
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[[Category: Wang W]]
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1KKF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKF OCA].
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==Reference==
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IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli., Hou Z, Wang W, Fromm HJ, Honzatko RB, J Biol Chem. 2002 Feb 22;277(8):5970-6. Epub 2001 Dec 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11741996 11741996]
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[[Category: Adenylosuccinate synthase]]
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[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Fromm, H J.]]
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[[Category: Honzatko, R B.]]
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[[Category: Hou, Z.]]
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[[Category: Wang, W.]]
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[[Category: Gtp-hydrolysing enzyme]]
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[[Category: Induced fit]]
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[[Category: Ligase]]
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[[Category: Purine nucleotide biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:28:16 2008''
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Current revision

Complex of E. coli Adenylosuccinate Synthetase with IMP, Hadacidin, Pyrophosphate, and Mg

PDB ID 1kkf

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