1kmt

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{{Seed}}
 
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[[Image:1kmt.png|left|200px]]
 
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==Crystal structure of RhoGDI Glu(154,155)Ala mutant==
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The line below this paragraph, containing "STRUCTURE_1kmt", creates the "Structure Box" on the page.
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<StructureSection load='1kmt' size='340' side='right'caption='[[1kmt]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kmt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KMT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kmt OCA], [https://pdbe.org/1kmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kmt RCSB], [https://www.ebi.ac.uk/pdbsum/1kmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kmt ProSAT]</span></td></tr>
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{{STRUCTURE_1kmt| PDB=1kmt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/1kmt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kmt ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of RhoGDI Glu(154,155)Ala mutant===
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==See Also==
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*[[Guanine nucleotide dissociation inhibitor|Guanine nucleotide dissociation inhibitor]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12454455}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12454455 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12454455}}
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==About this Structure==
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1KMT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KMT OCA].
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==Reference==
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The impact of Glu--&gt;Ala and Glu--&gt;Asp mutations on the crystallization properties of RhoGDI: the structure of RhoGDI at 1.3 A resolution., Mateja A, Devedjiev Y, Krowarsch D, Longenecker K, Dauter Z, Otlewski J, Derewenda ZS, Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):1983-91. Epub 2002, Nov 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12454455 12454455]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dauter, Z.]]
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[[Category: Dauter Z]]
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[[Category: Derewenda, Z S.]]
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[[Category: Derewenda ZS]]
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[[Category: Devedjiev, Y.]]
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[[Category: Devedjiev Y]]
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[[Category: Krowarsh, D.]]
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[[Category: Krowarsh D]]
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[[Category: Longenecker, K.]]
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[[Category: Longenecker K]]
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[[Category: Mateja, A.]]
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[[Category: Mateja A]]
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[[Category: Otlewski, J.]]
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[[Category: Otlewski J]]
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[[Category: Beta sandwich motif]]
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[[Category: Immunoglobulin fold]]
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[[Category: Isoprenyl-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:34:23 2008''
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Current revision

Crystal structure of RhoGDI Glu(154,155)Ala mutant

PDB ID 1kmt

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