1koa

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{{Seed}}
 
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[[Image:1koa.png|left|200px]]
 
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==TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS==
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The line below this paragraph, containing "STRUCTURE_1koa", creates the "Structure Box" on the page.
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<StructureSection load='1koa' size='340' side='right'caption='[[1koa]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1koa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KOA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1koa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1koa OCA], [https://pdbe.org/1koa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1koa RCSB], [https://www.ebi.ac.uk/pdbsum/1koa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1koa ProSAT]</span></td></tr>
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{{STRUCTURE_1koa| PDB=1koa | SCENE= }}
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</table>
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== Function ==
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===TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS===
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[https://www.uniprot.org/uniprot/UNC22_CAEEL UNC22_CAEEL] Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces.<ref>PMID:7190524</ref> <ref>PMID:18390597</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_9003756}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 9003756 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/1koa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_9003756}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1koa ConSurf].
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1KOA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOA OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Giant protein kinases: domain interactions and structural basis of autoregulation., Kobe B, Heierhorst J, Feil SC, Parker MW, Benian GM, Weiss KR, Kemp BE, EMBO J. 1996 Dec 16;15(24):6810-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9003756 9003756]
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Benian, G M.]]
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[[Category: Benian GM]]
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[[Category: Feil, S C.]]
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[[Category: Feil SC]]
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[[Category: Heierhorst, J.]]
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[[Category: Heierhorst J]]
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[[Category: Kemp, B E.]]
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[[Category: Kemp BE]]
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[[Category: Kobe, B.]]
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[[Category: Kobe B]]
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[[Category: Parker, M W.]]
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[[Category: Parker MW]]
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[[Category: Weiss, K R.]]
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[[Category: Weiss KR]]
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[[Category: Intrasteric regulation]]
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[[Category: Kinase]]
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[[Category: Twitchin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:38:19 2008''
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Current revision

TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS

PDB ID 1koa

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