1hv7

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(New page: 200px<br /><applet load="1hv7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hv7, resolution 1.7&Aring;" /> '''PORCINE PANCREATIC EL...)
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[[Image:1hv7.jpg|left|200px]]<br /><applet load="1hv7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hv7, resolution 1.7&Aring;" />
 
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'''PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A'''<br />
 
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==Overview==
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==PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A==
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The discovery of a potent intracellular inhibitor of human neutrophil, elastase which is orally active and has a long duration of action is, described. The pharmacodynamic and pharmacokinetic properties of a, trans-lactam development candidate, GW311616A, are described.
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<StructureSection load='1hv7' size='340' side='right'caption='[[1hv7]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HV7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=616:N-[2-(1-FORMYL-2-METHYL-PROPYL)-1-(4-PIPERIDIN-1-YL-BUT-2-ENOYL)-PYRROLIDIN-3-YL]-METHANESULFONAMIDE'>616</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv7 OCA], [https://pdbe.org/1hv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hv7 RCSB], [https://www.ebi.ac.uk/pdbsum/1hv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/1hv7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hv7 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1HV7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with SO4 and 616 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HV7 OCA].
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*[[Elastase 3D structures|Elastase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate., Macdonald SJ, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H, Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11294386 11294386]
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[[Category: Large Structures]]
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[[Category: Pancreatic elastase]]
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[[Category: Single protein]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Singh, O.M.]]
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[[Category: Singh OM]]
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[[Category: Skarzynski, T.]]
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[[Category: Skarzynski T]]
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[[Category: 616]]
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[[Category: SO4]]
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[[Category: serine protease-inhibitor complex]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:51:02 2007''
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Current revision

PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A

PDB ID 1hv7

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