1kqh

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{{Seed}}
 
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[[Image:1kqh.png|left|200px]]
 
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==NMR Solution Structure of the cis Pro30 Isomer of ACTX-Hi:OB4219==
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The line below this paragraph, containing "STRUCTURE_1kqh", creates the "Structure Box" on the page.
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<StructureSection load='1kqh' size='340' side='right'caption='[[1kqh]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kqh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hadronyche_infensa Hadronyche infensa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KQH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kqh OCA], [https://pdbe.org/1kqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kqh RCSB], [https://www.ebi.ac.uk/pdbsum/1kqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kqh ProSAT]</span></td></tr>
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{{STRUCTURE_1kqh| PDB=1kqh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/T21A_HADIN T21A_HADIN] Inhibits sodium channels (Nav) of insects.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The primary sequence and three-dimensional structure of a novel peptide toxin isolated from the Australian funnel-web spider Hadronyche infensa sp. is reported. ACTX-Hi:OB4219 contains 38 amino acids, including eight-cysteine residues that form four disulfide bonds. The connectivities of these disulfide bonds were previously unknown but have been unambiguously determined in this study. Three of these disulfide bonds are arranged in an inhibitor cystine-knot (ICK) motif, which is observed in a range of other disulfide-rich peptide toxins. The motif incorporates an embedded ring in the structure formed by two of the disulfides and their connecting backbone segments penetrated by a third disulfide bond. Using NMR spectroscopy, we determined that despite the isolation of a single native homologous product by RP-HPLC, ACTX-Hi:OB4219 possesses two equally populated conformers in solution. These two conformers were determined to arise from cis/trans isomerization of the bond preceding Pro30. Full assignment of the NMR spectra for both conformers allowed for the calculation of their structures, revealing the presence of a triple-stranded antiparallel beta sheet consistent with the inhibitor cystine-knot (ICK) motif.
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===NMR Solution Structure of the cis Pro30 Isomer of ACTX-Hi:OB4219===
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Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds.,Rosengren KJ, Wilson D, Daly NL, Alewood PF, Craik DJ Biochemistry. 2002 Mar 12;41(10):3294-301. PMID:11876637<ref>PMID:11876637</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_11876637}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1kqh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11876637 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11876637}}
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__TOC__
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</StructureSection>
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==About this Structure==
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQH OCA].
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==Reference==
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Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds., Rosengren KJ, Wilson D, Daly NL, Alewood PF, Craik DJ, Biochemistry. 2002 Mar 12;41(10):3294-301. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11876637 11876637]
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[[Category: Alewood, P F.]]
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[[Category: Craik, D J.]]
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[[Category: Daly, N L.]]
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[[Category: Rosengren, K J.]]
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[[Category: Wilson, D.]]
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[[Category: Cis-trans isomerisation]]
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[[Category: Cystine knot]]
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[[Category: Disulfide rich]]
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[[Category: Funnel web]]
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[[Category: Hadronyche infensa]]
[[Category: Hadronyche infensa]]
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[[Category: Nmr spectroscopy]]
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[[Category: Large Structures]]
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[[Category: Solution structure]]
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[[Category: Alewood PF]]
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[[Category: Spider venom]]
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[[Category: Craik DJ]]
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[[Category: Daly NL]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:46:18 2008''
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[[Category: Rosengren KJ]]
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[[Category: Wilson D]]

Current revision

NMR Solution Structure of the cis Pro30 Isomer of ACTX-Hi:OB4219

PDB ID 1kqh

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