1kql

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{{Seed}}
 
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[[Image:1kql.png|left|200px]]
 
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==Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution==
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The line below this paragraph, containing "STRUCTURE_1kql", creates the "Structure Box" on the page.
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<StructureSection load='1kql' size='340' side='right'caption='[[1kql]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KQL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kql OCA], [https://pdbe.org/1kql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kql RCSB], [https://www.ebi.ac.uk/pdbsum/1kql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kql ProSAT]</span></td></tr>
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{{STRUCTURE_1kql| PDB=1kql | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPM1_RAT TPM1_RAT] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/1kql_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kql ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution===
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==See Also==
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*[[Gcn4 3D Structures|Gcn4 3D Structures]]
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*[[Gnc4 3D Structures|Gnc4 3D Structures]]
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*[[Tropomyosin 3D structures|Tropomyosin 3D structures]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12032291}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12032291 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12032291}}
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[[Category: Rattus norvegicus]]
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[[Category: Saccharomyces cerevisiae]]
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==About this Structure==
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[[Category: Brown JH]]
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1KQL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_and_rattus_norvegicus Saccharomyces cerevisiae and rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQL OCA].
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[[Category: Cohen C]]
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[[Category: Li Y]]
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==Reference==
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[[Category: Mui S]]
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The crystal structure of the C-terminal fragment of striated-muscle alpha-tropomyosin reveals a key troponin T recognition site., Li Y, Mui S, Brown JH, Strand J, Reshetnikova L, Tobacman LS, Cohen C, Proc Natl Acad Sci U S A. 2002 May 28;99(11):7378-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12032291 12032291]
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[[Category: Reshetnikova L]]
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[[Category: Saccharomyces cerevisiae and rattus norvegicus]]
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[[Category: Strand J]]
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[[Category: Single protein]]
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[[Category: Tobacman LS]]
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[[Category: Brown, J H.]]
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[[Category: Cohen, C.]]
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[[Category: Li, Y.]]
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[[Category: Mui, S.]]
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[[Category: Reshetnikova, L.]]
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[[Category: Strand, J.]]
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[[Category: Tobacman, L S.]]
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[[Category: Coiled coil]]
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[[Category: Contractile protein]]
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[[Category: Four-helix bundle]]
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[[Category: Muscle regulation]]
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[[Category: Thin filament]]
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[[Category: Tropomyosin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:47:01 2008''
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Current revision

Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution

PDB ID 1kql

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