1kri

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{{Seed}}
 
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[[Image:1kri.png|left|200px]]
 
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==NMR Solution Structures of the Rhesus Rotavirus VP4 Sialic Acid Binding Domain without Ligand==
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The line below this paragraph, containing "STRUCTURE_1kri", creates the "Structure Box" on the page.
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<StructureSection load='1kri' size='340' side='right'caption='[[1kri]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kri]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_rotavirus_A_strain_RRV Simian rotavirus A strain RRV]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KRI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kri OCA], [https://pdbe.org/1kri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kri RCSB], [https://www.ebi.ac.uk/pdbsum/1kri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kri ProSAT]</span></td></tr>
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{{STRUCTURE_1kri| PDB=1kri | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VP4_ROTRH VP4_ROTRH] Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. It is subsequently lost, together with VP7, following virus entry into the host cell. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. In sialic acid-dependent and/or integrin-dependent strains, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1.<ref>PMID:20375171</ref> Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.<ref>PMID:20375171</ref> VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.<ref>PMID:20375171</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kr/1kri_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kri ConSurf].
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<div style="clear:both"></div>
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===NMR Solution Structures of the Rhesus Rotavirus VP4 Sialic Acid Binding Domain without Ligand===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11867517 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_11867517}}
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[[Category: Simian rotavirus A strain RRV]]
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[[Category: Dormitzer PR]]
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==About this Structure==
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[[Category: Harrison SC]]
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1KRI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rhesus_rotavirus Rhesus rotavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KRI OCA].
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[[Category: Sun Z-YJ]]
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[[Category: Wagner G]]
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==Reference==
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The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site., Dormitzer PR, Sun ZY, Wagner G, Harrison SC, EMBO J. 2002 Mar 1;21(5):885-97. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11867517 11867517]
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[[Category: Rhesus rotavirus]]
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[[Category: Single protein]]
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[[Category: Dormitzer, P R.]]
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[[Category: Harrison, S C.]]
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[[Category: Sun, Z Y.J.]]
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[[Category: Wagner, G.]]
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[[Category: Cell attachment]]
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[[Category: Galectin fold]]
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[[Category: Hemagglutinin]]
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[[Category: Lectin]]
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[[Category: Neutralization antigen]]
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[[Category: Outer capsid]]
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[[Category: Rotavirus]]
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[[Category: Sialic acid]]
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[[Category: Spike protein]]
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[[Category: Vp4]]
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[[Category: Vp8*]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:50:23 2008''
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Current revision

NMR Solution Structures of the Rhesus Rotavirus VP4 Sialic Acid Binding Domain without Ligand

PDB ID 1kri

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