1kt0

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{{Seed}}
 
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[[Image:1kt0.png|left|200px]]
 
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==Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes==
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The line below this paragraph, containing "STRUCTURE_1kt0", creates the "Structure Box" on the page.
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<StructureSection load='1kt0' size='340' side='right'caption='[[1kt0]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kt0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KT0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1kt0| PDB=1kt0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt0 OCA], [https://pdbe.org/1kt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kt0 RCSB], [https://www.ebi.ac.uk/pdbsum/1kt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kt0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1kt0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kt0 ConSurf].
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<div style="clear:both"></div>
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===Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes===
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12538866}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12538866 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12538866}}
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==Disease==
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Known disease associated with this structure: Major depressive disorder and accelerated response to antidepressant drug treatment OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602623 602623]]
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==About this Structure==
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1KT0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT0 OCA].
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==Reference==
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Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes., Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J, Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):868-73. Epub 2003 Jan 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12538866 12538866]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Cheung-Flynn J]]
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[[Category: Cheung-Flynn, J.]]
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[[Category: Clardy JC]]
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[[Category: Clardy, J C.]]
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[[Category: Rimerman RA]]
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[[Category: Rimerman, R A.]]
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[[Category: Scammell JG]]
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[[Category: Scammell, J G.]]
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[[Category: Sinars CR]]
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[[Category: Sinars, C R.]]
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[[Category: Smith DF]]
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[[Category: Smith, D F.]]
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[[Category: Fkbp-like ppiase]]
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[[Category: Tpr repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:56:12 2008''
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Current revision

Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes

PDB ID 1kt0

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