1kuh

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{{Seed}}
 
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[[Image:1kuh.png|left|200px]]
 
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==ZINC PROTEASE FROM STREPTOMYCES CAESPITOSUS==
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The line below this paragraph, containing "STRUCTURE_1kuh", creates the "Structure Box" on the page.
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<StructureSection load='1kuh' size='340' side='right'caption='[[1kuh]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kuh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_caespitosus Streptomyces caespitosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KUH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1kuh| PDB=1kuh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kuh OCA], [https://pdbe.org/1kuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kuh RCSB], [https://www.ebi.ac.uk/pdbsum/1kuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kuh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNPA_STRCS SNPA_STRCS] Specifically hydrolyzes the peptide bond at the imino side of aromatic residues.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/1kuh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kuh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A zinc endoprotease produced by Streptomyces caespitosus (ScNP) specifically hydrolyzes the peptide bond at the imino side of aromatic residues and is the smallest protease found to date. Although ScNP carries the zinc-binding sequence HEXXH, its primary structure of 132 amino acid residues differs from those of other known zinc metalloendoproteases. X-ray structural analysis of ScNP at 1.6 A resolution revealed that despite a lack of sequence homology, the common topological feature of main-chain folding and a beta-turn containing methionine, which is a feature of the zinc metalloendoprotease superfamily of metzincins, is conserved in ScNP. The zinc atom of ScNP is tetrahedrally ligated by the two histidines in the HEXXH sequence, an aspartate residue and a water molecule. Thus, ScNP represents a novel subfamily of metzincins with a HEXXHXXGXXD zinc-binding sequence. A plausible substrate recognition pocket to which aromatic residues bind is located near the catalytic zinc ion.
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===ZINC PROTEASE FROM STREPTOMYCES CAESPITOSUS===
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Structure of the zinc endoprotease from Streptomyces caespitosus.,Kurisu G, Kinoshita T, Sugimoto A, Nagara A, Kai Y, Kasai N, Harada S J Biochem. 1997 Feb;121(2):304-8. PMID:9089404<ref>PMID:9089404</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9089404}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1kuh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9089404 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9089404}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1KUH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_caespitosus Streptomyces caespitosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUH OCA].
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==Reference==
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Structure of the zinc endoprotease from Streptomyces caespitosus., Kurisu G, Kinoshita T, Sugimoto A, Nagara A, Kai Y, Kasai N, Harada S, J Biochem. 1997 Feb;121(2):304-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9089404 9089404]
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[[Category: Single protein]]
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[[Category: Streptomyces caespitosus]]
[[Category: Streptomyces caespitosus]]
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[[Category: Harada, S.]]
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[[Category: Harada S]]
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[[Category: Kai, Y.]]
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[[Category: Kai Y]]
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[[Category: Kasai, N.]]
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[[Category: Kasai N]]
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[[Category: Kinoshita, T.]]
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[[Category: Kinoshita T]]
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[[Category: Kurisu, G.]]
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[[Category: Kurisu G]]
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[[Category: Nagara, A.]]
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[[Category: Nagara A]]
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[[Category: Sugimoto, A.]]
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[[Category: Sugimoto A]]
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[[Category: Hydrolase]]
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[[Category: Metalloproteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:01:29 2008''
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Current revision

ZINC PROTEASE FROM STREPTOMYCES CAESPITOSUS

PDB ID 1kuh

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