1kwe

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[[Image:1kwe.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE CENTRAL CONSERVED REGION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT GLYCOPROTEIN G==
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The line below this paragraph, containing "STRUCTURE_1kwe", creates the "Structure Box" on the page.
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<StructureSection load='1kwe' size='340' side='right'caption='[[1kwe]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kwe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A_strain_Long Human respiratory syncytial virus A strain Long]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KWE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kwe OCA], [https://pdbe.org/1kwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kwe RCSB], [https://www.ebi.ac.uk/pdbsum/1kwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kwe ProSAT]</span></td></tr>
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{{STRUCTURE_1kwe| PDB=1kwe | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLYC_HRSVL GLYC_HRSVL] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (By similarity). Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BBG2Na is a recombinant protein, composed in part of carrier protein BB and of the central conserved domain of the attachment glycoprotein G of human respiratory syncytial virus (HRSV) subgroup A. This protein is a potent vaccine candidate against HRSV. G2Na contains several contiguous B-cell epitopes, occupying sequential positions in the linear sequence of the protein. One of the epitopes contains four cysteines that are completely conserved in known strains of HRSV and form a 'cysteine noose' motif. In this study, we analysed circular dichroism (CD) spectra of BBG2Na and its B-cell epitopes. We also used NMR and molecular dynamics simulations to determine the three-dimensional structure of the cysteine noose domain. We observed significant structural differences related to the length of peptides containing the cysteine noose. These differences show good correlation with the immunogenic activity of the peptides. It is shown that a single Val(171) addition induces a pronounced structure stabilization of the cysteine noose peptide G4a (1-4/2-3) (residues 172-187), which is associated with a 100-fold increase in its antigenicity vis-a-vis a G-protein specific monoclonal antibody.
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===SOLUTION STRUCTURE OF THE CENTRAL CONSERVED REGION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT GLYCOPROTEIN G===
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Structure-antigenicity relationship studies of the central conserved region of human respiratory syncytial virus protein G.,Sugawara M, Czaplicki J, Ferrage J, Haeuw JF, Power UF, Corvaia N, Nguyen T, Beck A, Milton A J Pept Res. 2002 Nov;60(5):271-82. PMID:12383117<ref>PMID:12383117</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1kwe" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12383117 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12383117}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human respiratory syncytial virus A strain Long]]
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1KWE is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWE OCA].
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[[Category: Large Structures]]
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[[Category: Beck A]]
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==Reference==
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[[Category: Corvaia N]]
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Structure-antigenicity relationship studies of the central conserved region of human respiratory syncytial virus protein G., Sugawara M, Czaplicki J, Ferrage J, Haeuw JF, Power UF, Corvaia N, Nguyen T, Beck A, Milton A, J Pept Res. 2002 Nov;60(5):271-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12383117 12383117]
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[[Category: Czaplicki J]]
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[[Category: Single protein]]
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[[Category: Ferrage J]]
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[[Category: Beck, A.]]
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[[Category: Haeuw JF]]
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[[Category: Corvaia, N.]]
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[[Category: Milon A]]
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[[Category: Czaplicki, J.]]
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[[Category: Nguyen T]]
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[[Category: Ferrage, J.]]
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[[Category: Power UF]]
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[[Category: Haeuw, J F.]]
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[[Category: Sugawara M]]
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[[Category: Milon, A.]]
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[[Category: Nguyen, T.]]
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[[Category: Power, U F.]]
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[[Category: Sugawara, M.]]
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[[Category: Cysteine nose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:09:01 2008''
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Current revision

SOLUTION STRUCTURE OF THE CENTRAL CONSERVED REGION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT GLYCOPROTEIN G

PDB ID 1kwe

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